L7757

利多卡因

≥98% (GC), powder, neuroprotective agent

• 同義詞: 2-二乙氨基-N-（2,6-二甲苯基）乙酰胺, 利多卡因, 赛洛卡因
• 經驗公式（希爾表示法）: C₁₄H₂₂N₂O
• CAS號碼: 137-58-6
• 分子量：: 234.34
• EC號碼: 205-302-8
• MDL號碼: MFCD00026733
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24896480
• NACRES: NA.77

屬性

• 產品名稱: 利多卡因, powder
• 形狀: powder
• SMILES 字串: CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• InChI 密鑰: NNJVILVZKWQKPM-UHFFFAOYSA-N
• 基因資訊: human ... CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scnn1a(25122)

描述

一般說明

Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.

應用

Lidocaine may be used for drug testing and for voltage clamp experiments.

生化／生理作用

Na⁺通道阻滞剂；IB类抗心律失常药。

Na⁺通道阻滞剂；在肠胃外给药后可迅速被吸收的IB类抗心律失常药。

Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na⁺) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves