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L6250

Sigma-Aldrich

石胆酸

≥95%

同義詞:

3α-羟基-5β-胆烷酸, 3α-羟基-5β-胆酸-24-羧酸, 5β-胆酸-24-羧酸-3α-醇

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About This Item

經驗公式（希爾表示法）:
C24H40O3
CAS號碼:
434-13-9
分子量：:
376.57
Beilstein:
3217757
EC號碼:
207-099-1
MDL號碼:
MFCD00003682
分類程式碼代碼:
12352106
PubChem物質ID:
24896429
NACRES:
NA.25

生物源

bovine bile
synthetic

化驗

≥95%

分子量

376.57 g/mol

mp

183-188 °C (lit.)

官能基

carboxylic acid

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC(O)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1

InChI 密鑰

SMEROWZSTRWXGI-HVATVPOCSA-N

基因資訊

human ... POLA1(5422) , TOP2A(7153)
rat ... Polb(29240)

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相關類別

一般說明

石胆酸是胆汁酸的低聚（乙二醇）衍生物。

應用

石胆酸已用于一项评估胆汁淤积及其对大鼠几个器官和组织的作用的研究。它也被用于一项通过TGF激活SMAD3来研究肝磷脂和胆汁酸稳态的调节的研究。

生化／生理作用

胆汁酸

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SLCM1507
SLCM1434
BCCG6225
SLCK0683
BCCF3135

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Satu Strandman et al.
The journal of physical chemistry. B, 117(1), 252-258 (2012-12-12)
Thermoresponsive characteristics of oligo(ethylene glycol) derivatives of lithocholic acid (LCA) depend on the hydrophilic/hydrophobic balance of the compounds. Below a threshold temperature (∼30 °C), one of the derivatives, LCA(EG(4))(2), self-assembles in water into hollow nanotubes that form thixotropic gels at
Katarzyna Magiera et al.
Cell chemical biology, 24(4), 458-470 (2017-03-28)
USP2a is a deubiquitinase responsible for stabilization of cyclin D1, a crucial regulator of cell-cycle progression and a proto-oncoprotein overexpressed in numerous cancer types. Here we report that lithocholic acid (LCA) derivatives are inhibitors of USP proteins, including USP2a. The
Vincent R Richard et al.
Aging, 5(4), 234-269 (2013-04-05)
Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in yeast, we
Claudiu Saracut et al.
Acta cirurgica brasileira, 30(9), 624-631 (2015-10-16)
To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon. The study used C57BL6 female mice divided into four groups.
Alan F Hofmann
Drug metabolism reviews, 36(3-4), 703-722 (2004-11-24)
Lithocholic acid, a monohydroxy, secondary bile acid, is formed by bacterial 7-dehydroxylation of the primary bile acid chenodeoxycholic acid (CDCA) and of the secondary bile acid ursodeoxycholic acid (UDCA). Lithocholic acid and its precursor CDCA are toxic when fed to
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Fast and Robust HPLC Separation of Bile Acids and Conjugates with Ascentis Express C18

This method is particularly useful in research into the role of individual bile acids as signaling molecules; suitable for clinical laboratories to investigate potential mechanisms linked to gut hormone profiles and glycemic control.

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