L2420

Monoclonal Anti-LRP1 antibody produced in mouse

~1.0 mg/mL, clone LRP1-11, purified immunoglobulin, buffered aqueous solution

• 同義詞: Anti-A2MR, Anti-APOER, Anti-APR, Anti-Apolipoprotein E receptor, Anti-Apolipoprotein receptor, Anti-CD91, Anti-LRP, Anti-Lipoprotein receptor-related protein, Anti-Low density lipoprotein receptor-related protein 1
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: LRP1-11, monoclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~500 kDa
• 物種活性: human, rat, mouse
• 濃度: ~1.0 mg/mL
• 技術: indirect immunofluorescence: suitable; western blot: 1-2 μg/mL
• 同型: IgG1
• UniProt登錄號: Q07954
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... LRP1(4035) ; mouse ... Lrp1(16971) , Lrp1(299858)

描述

一般說明

Monoclonal Anti-LRP1 (mouse IgG1 isotype) is derived from the hybridoma LRP1-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human LRP1, conjugated to KLH. LDL receptor family. Low-density lipoprotein (LDL) receptor related protein 1 (LRP1) gene is mapped to human chromosome 12q13.3. LRP1 protein, belongs to the LDL receptor family. LRP1, a single-chain 600 kDa type I transmembrane glycosylated precursor protein, is produced in the endoplasmic reticulum. This protein is proteolytically cleaved in the Golgi complex into two subunits including 85-kDa membrane-bound C-terminal membrane spanning subunit and a noncovalently attached 515-kDa N-terminal subunit.

特異性

Monoclonal Anti-LRP1 recognizes human, rat, and mouse LRP1.

應用

Monoclonal Anti-LRP1 antibody produced in mouse has been used in:

• immunoblotting
• enzyme linked immunosorbent assay
• immunofluorescence

生化／生理作用

Low density lipoprotein receptor related protein 1 (LRP1) plays an essential role in early stages of embryonic development. It aids in lipoprotein metabolism, proteinase regulation, activation of lysosomal enzymes and cellular entry of viruses and toxins. Additionally, It is also implicated in cell signaling pathways, cell migration, and neurodevelopment. LRP1 interacts with at least 30 different ligands including lipoproteins, proteinases, proteinase-inhibitor complexes, extra cellular matrix (ECM) proteins and various intracellular proteins. Furthermore, LDL receptor related protein 1 also has an ability to associate with bacterial toxins and viruses.

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

儲存和穩定性

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.

免責聲明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable