推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
溶解度
DMSO: >20 mg/mL
儲存溫度
2-8°C
SMILES 字串
CC(Sc1nc2ccccc2[nH]1)C(=O)N\N=C\c3cc(Br)ccc3O
InChI
1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,23H,1H3,(H,20,21)(H,22,24)/b19-9+
InChI 密鑰
WILMXUAKQKGGCC-DJKKODMXSA-N
應用
KH7已被用于：
- 作为可溶性腺苷酸环化酶（sAC）拮抗剂，用于研究其对精子细胞中1型瞬时受体（TRPV1）作用介导的信号通路的影响。
- 作为选择性sAC拮抗剂，用于研究其对精子细胞中质子门控通道（HV1）诱导作用的信号通路的影响。
- 作为sAC抑制剂，用于研究其对单磷酸化肌球蛋白轻链（pMLC）中cAMP增加的影响。
生化／生理作用
KH7 是可溶性腺苷酸环化酶的选择性抑制剂。
KH7 是可溶性腺苷酸环化酶的选择性抑制剂。可溶性腺苷酸环化酶（sAC）泛表达，是cAMP 信号传递的重要组成部分。
特點和優勢
这种化合物是环核苷酸研究的特色产品。点击此处查看更多特色环核苷酸产品。登录sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。
適合性
在洗涤剂的作用下，KH7 对 sAC 无活性。当用于细胞实验时，KH7 在50μM以上的浓度下显示出非特异性膜破坏效应。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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