跳轉至內容
Merck
全部照片(1)

重要文件

I6658

Sigma-Aldrich

Isradipine

≥98% (HPLC), solid

同義詞:

4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C19H21N3O5
CAS號碼:
分子量::
371.39
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

描述

Store under nitrogen

化驗

≥98% (HPLC)

形狀

solid

顏色

yellow

溶解度

DMSO: >10 mg/mL

起源

Novartis

儲存溫度

2-8°C

SMILES 字串

COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C

InChI

1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

InChI 密鑰

HMJIYCCIJYRONP-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

相關類別

應用

Isradipine has been used to explore neuroprotective activity.

生化/生理作用

Isradipine is considered as an active calcium channel blocker, used to treat hypertension.
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.
L-type calcium channel blocker; antihypertensive.

特點和優勢

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Petra Geier et al.
American journal of physiology. Cell physiology, 300(4), C937-C949 (2011-01-14)
L-type voltage-gated calcium channels (LTCCs) have long been considered as crucial regulators of neuronal excitability. This role is thought to rely largely on coupling of LTCC-mediated Ca(2+) influx to Ca(2+)-dependent conductances, namely Ca(2+)-dependent K(+) (K(Ca)) channels and nonspecific cation (CAN)
Rodrigo Almeida Simões et al.
Analytical and bioanalytical chemistry, 399(7), 2435-2443 (2011-01-20)
An enantioselective liquid chromatographic method using two-phase hollow fiber liquid-phase microextraction (HF-LPME-HPLC) was developed for the determination of isradipine (ISR) enantiomers and its main metabolite (pyridine derivative of isradipine, PDI) in microsomal fractions isolated from rat liver. The analytes were
C Savio Chan et al.
Movement disorders : official journal of the Movement Disorder Society, 25 Suppl 1, S63-S70 (2010-02-27)
Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology. There is no cure or proven strategy for slowing the progression of the disease. Although there are signs of pathology in many brain regions, the core symptoms of PD
Vincent Malaterre et al.
Drug development and industrial pharmacy, 35(4), 433-439 (2008-11-08)
Push-pull osmotic systems have been developed to deliver poorly soluble drugs in a modified-release fashion. The aim of this study was to investigate the influence of the tablet core factors on the drug release kinetics and loadability. The release kinetics
Philip F Copenhaver et al.
Disease models & mechanisms, 4(5), 634-648 (2011-05-21)
A growing body of evidence supports the 'calcium hypothesis' of Alzheimer's disease (AD), which postulates that a variety of insults might disrupt the homeostatic regulation of neuronal calcium (Ca(2+)) in the brain, resulting in the progressive symptoms that typify the

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務