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Key Documents

I2511

Sigma-Aldrich

IgG 来源于人类血清

reagent grade, ≥95% (HPLC), buffered aqueous solution

同義詞:

人 IgG

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.46

共軛

unconjugated

品質等級

等級

reagent grade

化驗

≥95% (HPLC)

形狀

buffered aqueous solution

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

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一般說明

IgG抗体亚型是免疫系统中含量最高的血清免疫球蛋白。它由B细胞分泌,存在于血液和细胞外液中,可防止细菌、真菌和病毒引起的感染。母体IgG可通过胎盘转移至胎儿,胎盘对新生儿免疫防御感染至关重要。
人IgG是从正常人血清中通过沉淀和凝胶过滤技术纯化得来的。

應用

纯化人IgG已用于:-
  • 作为流式细胞仪的封闭抗体
  • 作为染色质免疫沉淀试验中的阴性对照
  • 免疫沉淀法沉淀人喉表皮样癌细胞中的IgG
  • 作为酶联免疫吸附试验的标准品

生化/生理作用

免疫球蛋白G(IgG)可调节免疫应答,例如吞噬作用,并且还可参与自身免疫疾病的发展。IgG1可调节小鼠的补体结合。

外觀

0.01M磷酸盐缓冲盐水溶液,pH 7.4,含有15 mM叠氮化钠

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

In-Kyu Yoon et al.
The American journal of tropical medicine and hygiene, 72(6), 714-718 (2005-06-21)
Volunteers vaccinated with a candidate malaria vaccine containing merozoite surface protein 1(42) (MSP-1(42)) exhibit antibodies to MSP-1(42) that are measured by enzyme-linked immunosorbent assay (ELISA). The purpose of this study was to make a human reference standard for MSP-1(42) antibody
Kentaro Matsuda et al.
The Journal of allergy and clinical immunology, 116(6), 1357-1363 (2005-12-13)
Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen. To determine whether human IgE, in the absence of known specific
D R McArthur et al.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 11(7), 775-782 (2008-08-12)
Trials investigating colorectal cancer (CRC) chemoprophylaxis with cyclooxygenase-2 (COX-2) inhibitors have been discontinued because of adverse cardiovascular effects. Nevertheless, identification of patients where beneficial, chemo-prophylactic effects of COX-2 inhibitors outweigh side-effects may be possible; this study aimed to investigate whether
Charles C Chu et al.
Blood, 112(13), 5122-5129 (2008-09-25)
Leukemic B lymphocytes of a large group of unrelated chronic lymphocytic leukemia (CLL) patients express an unmutated heavy chain immunoglobulin variable (V) region encoded by IGHV1-69, IGHD3-16, and IGHJ3 with nearly identical heavy and light chain complementarity-determining region 3 sequences.
Alberto Sinibaldi et al.
Biosensors, 8(3) (2018-07-26)
Optical biosensors based on one-dimensional photonic crystals sustaining Bloch surface waves are proposed to study antibody interactions and perform affinity studies. The presented approach utilizes two types of different antibodies anchored at the sensitive area of a photonic crystal-based biosensor.

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