H9666

Nerve Growth Factor β Human

HumanKine^®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• 同義詞: NGF-β human
• MDL號碼: MFCD00164982
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 產品名稱: Nerve Growth Factor β Human, NGF-β, recombinant, expressed in HEK 293 cells, HumanKine^™, suitable for cell culture
• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in HEK 293 cells
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized powder
• 效力: ≤3 ng/mL EC₅₀
• 品質: endotoxin tested
• 分子量: 13 kDa (non-glycosylated)
• 包裝: pkg of 10 μg
• 製造商／商標名: HumanZyme
• 技術: cell culture | mammalian: suitable
• 雜質: <1 EU/μg
• 儲存溫度: −20°C

描述

一般說明

HumanKine NGF-β is expressed in human 293 cells as a non-glycosylated, non-disulfide bonded 13 kDa homodimer.

NGF-β belongs to the nerve growth factor protein superfamily. It is a key growth factor in target-mediated regulation of peripheral innervation. During development, NGF-β regulates nerve cell death, synaptic connectivity, fiber guidance, and dendritic morphology. The presence of NGF-β in immune cells and endocrine cells as well as in the CNS limbic areas suggests that it may function as an intracellular messenger to regulate the body′s response to stress.

The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.

應用

Nerve Growth Factor β Human has been used as a neurotrophic agent in luciferase reporter assay using mammalian cells.

生化／生理作用

Nerve Growth Factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFB is known to promote cancer cell proliferation and metastasis. It is associated with lung, breast, prostatic and pancreatic cancers. In animal models, NGFB is observed to prevent cholinergic neuron loss and enhances memory.

外觀

Lyophilized from a 0.2 μm filtered solution of 1X PBS

分析報告

The activity was determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells (human erythroleukemic indicator cell line).

法律資訊

3D Insert is a trademark of 3D Biotek, LLC

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable