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重要文件

H6503

Sigma-Aldrich

L-同型半胱氨酸硫内酯 盐酸盐

≥98% (TLC)

同義詞:

L-2-氨基-4-巯基丁酸 1,4-硫代内酯 盐酸盐

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About This Item

經驗公式(希爾表示法):
C4H7NOS · HCl
CAS號碼:
分子量::
153.63
Beilstein:
3911455
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26

產品名稱

L-同型半胱氨酸硫内酯 盐酸盐, ≥98% (TLC)

化驗

≥98% (TLC)

形狀

powder

顏色

white

mp

185 °C

應用

detection
peptide synthesis

SMILES 字串

Cl[H].N[C@H]1CCSC1=O

InChI

1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

InChI 密鑰

ZSEGSUBKDDEALH-DFWYDOINSA-N

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應用


  • Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart:研究DL-同型半胱氨酸硫内酯对心脏功能的作用,揭示它的心血管研究用途和治疗潜力(Zivkovic et al., 2013)。

  • Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease:研究L-同型半胱氨酸硫内酯如何影响冠心病治疗中的血小板反应,说明它的心血管治疗意义(Karolczak et al., 2013)。

生化/生理作用

同型半胱氨酸硫代内酯是一种胺反应剂,被用于研究蛋白质翻译后修饰,尤其是赖氨酸残基的修饰。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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Derrick L Sauls et al.
Thrombosis research, 127(6), 576-581 (2011-02-15)
We have shown that homocysteinemic rabbits have altered fibrinogen that forms fibrin clots with increased resistance to fibrinolysis. Homocysteine thiolactone is a metabolite of homocysteine (Hcys) that can react with amines and introduce a new sulfhydryl group into proteins. Recent
A Rašić-Marković et al.
Acta physiologica Hungarica, 98(1), 17-26 (2011-03-11)
The aim of our study was to investigate the effects of ifenprodil and MK-801 on D,L-homocysteine thiolactone induced seizures in adult rats.Male Wistar rats were divided into following groups: 1. Saline-treated (C, n=10); 2. D,L-homocysteine thiolactone 8 mmol/kg, i.p. (H
Han-Hsin Chang et al.
Molecular vision, 17, 1946-1956 (2011-08-19)
Hyperhomocysteinemia is known to cause degeneration of retinal ganglion cells, but its influence on photoreceptors remains largely unknown. In particular, the role of homocysteine-thiolactone (Hcy-T)--the physiologic metabolite of homocysteine that has been proven to be more cytotoxic than homocysteine itself--as
Hieronim Jakubowski
Acta biochimica Polonica, 58(2), 149-163 (2011-06-07)
All living organisms conduct protein synthesis with a high degree of accuracy maintained in the transmission and flow of information from a gene to protein product. One crucial 'quality control' point in maintaining a high level of accuracy is the
Joanna Malinowska et al.
Platelets, 23(5), 409-412 (2011-10-21)
Homocysteine (Hcys) and homocysteine thiolactone (HTL) concentrations in organism are correlated with a number of serious pathologies. In the literature, there are few papers describing studies on the effects of homocysteine on proteins that participate in blood coagulation and fibrinolysis

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