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H6166

Sigma-Aldrich

Interferon α 2B human

IFN-α 2B, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

同義詞:

IFN α 2B, IFN Alfa 2b, INF α 2B, INF Alfa 2b, Interferon Alfa 2b

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

生物源

human

品質等級

重組細胞

expressed in HEK 293 cells

化驗

≥95% (SDS-PAGE)

形狀

lyophilized powder

效力

≤0.12 ng/mL EC50

品質

endotoxin tested

分子量

dimer 16 kDa (glycosylated)

包裝

poly bottle of 10 μg (in poly bottle)

製造商/商標名

HumanZyme

技術

cell culture | mammalian: suitable

雜質

≤1EU/mg

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... IFNA2(3440)

一般說明

The interferon α 2 (IFN-α2) exists in three forms 2a, 2b and 2c. It consists of 165 amino acids and five α helices. IFN-α2B is found structurally stable at pH 7. The recombinant IFN-α is nonglycosylated compared to the natural human IFN-α.

生化/生理作用

Interferon α 2B (IFN-α 2B) belongs to the type I interferon protein family. It is produced by many cell types in response to viral infection. IFN-α 2B has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T-cells.

外觀

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

準備報告

HumanKine IFN-α 2B is a glycosylated monomer expressed in HEK 293 cells with an apparent molecular mass of 16 kDa. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

分析報告

The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV ( vesicular stomatitis virus).

法律資訊

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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