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Key Documents

F5062

Sigma-Aldrich

Fmoc-Lys(Me)3-OH Chloride

≥97%, for peptide synthesis

同義詞:

Fmoc-Lys(Me3Cl)-OH, N-alpha-Fmoc-N-alpha-trimethyl-N-L-lysine · chloride

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About This Item

經驗公式(希爾表示法):
C24H31ClN2O4
CAS號碼:
分子量::
446.97
分類程式碼代碼:
12352209
NACRES:
NA.26

product name

Fmoc-Lys(Me)3-OH Chloride, ≥97%

化驗

≥97%

形狀

liquid

反應適用性

reaction type: Fmoc solid-phase peptide synthesis

應用

peptide synthesis

官能基

Fmoc

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1

InChI 密鑰

XUJRNPVABVHOAJ-FTBISJDPSA-N

一般說明

Fmoc protected N-trimethyl lysine

應用

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:
  • Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.
  • Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.
  • Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Multifunctional Reagents for Quantitative Proteome?Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development.
Broncel M, et al.
Angewandte Chemie (International Edition in English), 54(20), 5948-5951 (2015)
Novel peptide linkers for highly potent antibody? auristatin conjugate.
Doronina S O, et al.
Bioconjugate Chemistry, 19(10), 1960-1963 (2008)
Sequential Peptide Ligation by Combining the Cys?Pro Ester (CPE) and Thioester Methods and Its Application to the Synthesis of Histone H3 Containing a Trimethyl Lysine Residue.
Kawakami T, et al.
Bulletin of the Chemical Society of Japan, 86(6), 690-697 (2013)

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