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H2519

Sigma-Aldrich

肝素酶 I 来源于肝素黄杆菌

Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)

同義詞:

肝素裂解酶I, 肝素酶

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About This Item

CAS號碼:
9025-39-2
酶委員會編號:
4.2.2.7 (BRENDA, IUBMB)
MDL號碼:
MFCD00131317
分類程式碼代碼:
12352204
NACRES:
NA.54

共軛

conjugate (Glucosaminoglycan)

品質等級

200

形狀

lyophilized solid

比活性

≥200 units/mg protein (enzyme + BSA)

分子量

42.8 kDa

應用

diagnostic assay manufacturing

儲存溫度

−20°C

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相關類別

應用

来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I已被用于：
  • 消化血浆样品
  • 研究培养基、洗涤和超声处理对肺炎衣原体(Chlamydia pneumonia)感染性的影响
  • 酶法去除人横纹肌肉瘤细胞表面的硫酸乙酰肝素

生化／生理作用

来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I通过裂解肝素AT III结合位点处的α-糖苷键而发挥作用。这就产生了小的寡糖碎片。肝素酶 I 可以中和蛋白质的抗凝作用。肝素酶I的半衰期为15-18分钟。

單位定義

在25 °C、pH 7.5条件下，一个单位（Sigma单位）每小时可形成0.1 μ摩尔不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。

其他說明

有关复合碳水化合物分析酶的更多信息，请见www.sigma-aldrich.com/enzymeexplorer

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H334

防範說明

P261 - P284 - P501

危險分類

Resp. Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SLCJ7666
SLCJ7667
SLCJ5446
SLCG4654
SLCB1106

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Avery Davis Bell et al.
Nature, 583(7815), 259-264 (2020-06-05)
Meiosis, although essential for reproduction, is also variable and error-prone: rates of chromosome crossover vary among gametes, between the sexes, and among humans of the same sex, and chromosome missegregation leads to abnormal chromosome numbers (aneuploidy)1-8. To study diverse meiotic
Udayanath Aich et al.
Analytical chemistry, 83(20), 7815-7822 (2011-08-26)
Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated with the advent of severe adverse
Coxsackievirus A16 utilizes cell surface heparan sulfate glycosaminoglycans as its attachment receptor
Zhang X, et al.
Emerging microbes & infections, 6(7), e65-e65 (2017)
Differential expression of plasma microRNA in preeclamptic patients at delivery and 1 year postpartum
Murphy MSQ, et al.
American Journal of Obstetrics and Gynecology, 213(3), 367-e1-367-e1 (2015)
Methodological aspects affecting the infectivity of Chlamydia pneumoniae in cell cultures in vitro
Yan Y, et al.
Journal of Microbiological Methods, 61(1), 127-130 (2005)
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Carbohydrate Analysis

A key resource feature at our Enzyme Explorer section of biochemicals is "Enzymes for Carbohydrate Analysis and Digestion." Offering kits, reagents, analysis, lists of enzymes related to PTM and carbohydrate metabolism.

Carbohydrate Analysis

A key resource feature at our Enzyme Explorer section of biochemicals is "Enzymes for Carbohydrate Analysis and Digestion." Offering kits, reagents, analysis, lists of enzymes related to PTM and carbohydrate metabolism.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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