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Key Documents

H0261

Sigma-Aldrich

DL-β-羟基丁酰基辅酶 A 锂盐

≥90%

同義詞:

DL -3-羟基丁酰辅酶A

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About This Item

經驗公式(希爾表示法):
C25H42N7O18P3S
CAS號碼:
分子量::
853.62
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

品質等級

化驗

≥90%

儲存溫度

−20°C

SMILES 字串

[Li].CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23

InChI

1S/C25H42N7O18P3S.Li.H/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32;;/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41);;

InChI 密鑰

HNPHARRBSFXZAL-UHFFFAOYSA-N

應用

DL-β-羟基丁酰辅酶A锂盐已用于:

  • 作为HSD17B4蛋白酶检测的底物
  • 作为Hc-DHS-28及突变蛋白特异性和动力学检测底物
  • 作为S-腺苷-L-高半胱氨酸水解酶(AHCY)体外乙酰化反应的缓冲液组分

生化/生理作用

3-羟基丁酰基辅酶 A (HBCoA) 通过聚羟基丁酸 (PHB) 合成酶转化为细菌聚羟基脂肪酸酯 (PHB)。3-羟基丁酰基辅酶 A 是用于测定 β-羟酰 CoA 脱氢酶。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Ping Li et al.
Biochemistry, 48(39), 9202-9211 (2009-08-29)
Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each 40 kDa). The polymerization involves covalent catalysis
Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
Cornille E, Abou-Hamdan M, et al.
BMC Neuroscience, 23, 51-51 (2010)
An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation
Xie J, et al.
CCS Chemistry, 4(1), 304-317 (2022)
Yi Yang et al.
International journal for parasitology, 50(12), 945-957 (2020-08-29)
Haemonchus contortus could enter the diapause stage to avoid hostile conditions, however the inducing mechanism still remains poorly understood. A similar dauer strategy exists in Caenorhabditis elegans, and dauer phenomones, which are produced through a four step cycle of peroxisomal
Der-Shyan Sheu et al.
Analytical biochemistry, 393(1), 62-66 (2009-06-17)
This study presents a method to detect active polyhydroxyalkanoate (PHA) synthase on a polyacrylamide gel that combines the polyhydroxybutyrate (PHB) polymerization reaction with Sudan Black B staining. After separation of the protein samples on a modified sodium dodecyl sulfate-polyacrylamide gel

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