G9893

Gliotoxin

from Gliocladium fimbriatum, ≥98% (HPLC), powder, immunomodulating agent

• 同義詞: Aspergillin
• 經驗公式（希爾表示法）: C₁₃H₁₄N₂O₄S₂
• CAS號碼: 67-99-2
• 分子量：: 326.39
• Beilstein: 50675
• MDL號碼: MFCD00058534
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24895384
• NACRES: NA.77

屬性

• 產品名稱: 胶霉毒素 来源于胶霉,
• 品質等級: 200
• 抗生素活性譜: viruses
• 作用方式: DNA synthesis | interferes; enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
• InChI: 1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
• InChI 密鑰: FIVPIPIDMRVLAY-RBJBARPLSA-N

描述

一般說明

Chemical structure: epipolythiodioxopiperazine

Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.

應用

Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.

Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro.

生化／生理作用

Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P301 + P310
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges