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重要文件

G0903

Sigma-Aldrich

γ-Glu-Cys

≥80% (HPLC), suitable for ligand binding assays

同義詞:

γ-L-谷氨酰基-L半胱氨酸, 去甘氨酸-谷胱甘肽的还原形式

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About This Item

經驗公式(希爾表示法):
C8H14N2O5S
CAS號碼:
分子量::
250.27
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

產品名稱

γ-Glu-Cys, ≥80% (HPLC)

品質等級

化驗

≥80% (HPLC)

形狀

powder

成份

Peptide content, ≥60% elemental analysis

技術

ligand binding assay: suitable

顏色

white to off-white

儲存溫度

−20°C

SMILES 字串

N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O

InChI

1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1

InChI 密鑰

RITKHVBHSGLULN-WHFBIAKZSA-N

尋找類似的產品? 前往 產品比較指南

Amino Acid Sequence

Glu-Cys

應用

γ-Glu-Cys可用于研究谷胱甘肽合成酶的活性位点和动力学。它也被用于从拟南芥 组织中提取和量化低分子量硫醇。

生化/生理作用

γ-L-谷氨酰基-L-半胱氨酸(γ-Glu-Cys)是用于通过谷胱甘肽合成酶生物合成L-谷胱甘肽的底物。γ-Glu-Cys通过裂解谷胱甘肽的Cys-Gly肽键而产生。它对植物螯合素的形成也是必需的,植物螯合素是富含半胱氨酸的硫醇反应性肽。

外觀

从0.1%TFA中冻干获得。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Runa Njålsson et al.
Human genetics, 116(5), 384-389 (2005-02-18)
Glutathione synthetase (GS) deficiency is a rare autosomal recessive disorder. The clinical phenotype varies widely, and nearly 30 different mutations in the GSS gene have been identified. In the present study, genotype, enzyme activity, metabolite levels and clinical phenotype were
H Yamaguchi et al.
Journal of molecular biology, 229(4), 1083-1100 (1993-02-20)
Glutathione synthetase (gamma-L-glutamyl-L-cysteine: glycine ligase (ADP-forming) EC 6.3.2.3: GSHase) catalyzes the synthesis of glutathione from gamma-L-glutamyl-L-cysteine and Gly in the presence of ATP. The enzyme from Escherichia coli is a tetramer with four identical subunits of 316 amino acid residues.
Xueni Sun et al.
Analytica chimica acta, 1080, 127-137 (2019-08-15)
Glutathione is an essential intra- and extracellular antioxidant. The level of glutathione in the body is highly related to different disease states and is a useful indicator of disease risk and oxidative stress status. We have developed a sensitive, selective
Hemantaranjan, A.
Advances In Plant Physiology (2012)
Chava B Pocernich et al.
Biochimica et biophysica acta, 1822(5), 625-630 (2011-10-22)
Oxidative stress has been associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display extensive oxidative stress as indexed by protein oxidation, lipid peroxidation, free radical formation, DNA

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