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Key Documents

G1404

Sigma-Aldrich

还原型谷胱甘肽乙酯

≥90% (TLC)

同義詞:

γ-GLU-半胱氨酸 - 甘氨酸 - OET, GSH-MEE

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About This Item

經驗公式(希爾表示法):
C12H21N3O6S
CAS號碼:
分子量::
335.38
MDL號碼:
分類程式碼代碼:
12161504
PubChem物質ID:
NACRES:
NA.26

product name

还原型谷胱甘肽乙酯, ≥90% (TLC)

品質等級

化驗

≥90% (TLC)

形狀

powder

顏色

white to off-white

儲存溫度

−20°C

SMILES 字串

CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O

InChI

1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1

InChI 密鑰

JKRODHBGNBKZLE-YUMQZZPRSA-N

Amino Acid Sequence

Glu-Cys-Gly-OEt

應用

还原型谷胱甘肽乙酯已被用于:
  • 提高小鼠成纤维细胞 L929 细胞内谷胱甘肽水平
  • 作为 果翅目昆虫 (Sf) 9 细胞的培养基补充
  • 以评价其对脊髓损伤后脂质过氧化作用

生化/生理作用

谷胱甘肽乙酯(还原型)可通过抑制Melan-A细胞中的酪氨酸酶活性来抑制黑色素合成。它的抗黑色素生成功能可用于治疗皮肤色素沉着过度性疾病。从胰腺分离胰岛时,添加谷胱甘肽乙酯(GEE)可减少活性氧物质生成和细胞凋亡。
还原型谷胱甘肽乙酯 (GSH—MEE) 是 GSH 的膜/脂质渗透性衍生物,可用于部分补充细胞内遭受半胱氨酸和/或 GSH 耗竭的 GSH 供应。GSH-MEE 被细胞内酯酶水解释放 GSH,从而增加细胞内 GSH 的浓度。 防止动物细胞中对乙酰氨基酚的毒性作用。保护人体淋巴细胞和皮肤成纤维细胞免受辐射造成的损伤。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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