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G0251

Sigma-Aldrich

β-葡萄糖醛酸酶 来源于牛肝脏

Type B-1, ≥1,000,000 units/g solid

同義詞:

牛肝β-葡萄糖醛酸酶, β-葡萄糖醛酸苷酶

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About This Item

CAS號碼:
9001-45-0
酶委員會編號:
3.2.1.31 (BRENDA, IUBMB)
EC號碼:
232-606-8
MDL號碼:
MFCD00130629
分類程式碼代碼:
12352204
NACRES:
NA.54

種類

Type B-1

品質等級

200

形狀

solid

比活性

≥1,000,000 units/g solid

儲存溫度

−20°C

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相關類別

一般說明

β-葡糖醛酸糖苷酶（GUSB）是一种溶酶体酶，存在于动物、植物和细菌中。这种糖苷外切酶在脾脏、肝脏和肾脏中的活性很高。牛肝β葡糖醛酸糖苷酶（BLG）是同源四聚体，分子量为290 kDa。

應用

β-葡萄糖醛酸酶在GUS测定中可用作报告基因以监测基因的表达。
β来自牛肝的-葡糖醛酸苷酶已被用于β-葡糖醛酸苷酶抑制试验，用于研究苦味叶下珠提取物和分离的活性成分对β-葡糖醛酸苷酶的抑制作用。它还被用于进行脱葡萄糖醛酸化。

生化／生理作用

β-葡糖醛酸糖苷酶（GUSB）缺乏会导致VII型粘多糖贮积症（MPSVII），从而导致溶酶体在大脑中的存储。类固醇激素的葡糖醛酸糖苷酶在组织中的整合β可以在GUSB的帮助下完成。
β-葡萄糖醛酸酶可催化复合碳水化合物的分解。在人体中，它可将结合胆红素转化为非结合的形式，使胆红素利于重吸收。

單位定義

在37℃，pH 5.0（30分钟检测）条件下，一个Sigma或改良的Fishman单位可每小时从酚酞葡糖苷酸中释放1.0 μg酚酞。

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H317,H334

危險分類

Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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A D Fraser
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Determination of furosemide with its acyl glucuronide in human plasma and urine by means of direct gradient high-performance liquid chromatographic analysis with fluorescence detection Preliminary pharmacokinetics and effect of probenecid
Vree TB, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 655(1), 53-62 (1994)
Uzma Salar et al.
European journal of medicinal chemistry, 125, 1289-1299 (2016-11-26)
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P Jakobsen et al.
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Enzymatic Assay of ß-Glucuronidase (EC 3.2.1.31) from Helix Pomatia and Bovine Liver

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Enzymatic Assay of ß-Glucuronidase (EC 3.2.1.31) from Helix Pomatia and Bovine Liver

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