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F131

Sigma-Aldrich

FPL 64176

≥98% (HPLC), powder

同義詞:

2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester

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About This Item

經驗公式（希爾表示法）:
C22H21NO3
CAS號碼:
120934-96-5
分子量：:
347.41
MDL號碼:
MFCD00274043
分類程式碼代碼:
12352200
PubChem物質ID:
24277836
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated
protect from light

顏色

white to beige

溶解度

DMSO: >20 mg/mL (Solutions should be freshly prepared.)
H2O: insoluble

儲存溫度

2-8°C

SMILES 字串

COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cc3ccccc3

InChI

1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3

InChI 密鑰

MDMWHKZANMNXTF-UHFFFAOYSA-N

基因資訊

rat ... Cacnb3(25297)

相關類別

生化／生理作用

Potent Ca2+ channel (L-type) activator.

注意

Photosensitive

法律資訊

Manufactured and sold with permission from Astra Charnwood.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
043M4702V
BGBB9231
010M4607
028K4622
055K4614

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Julie A Gaasch et al.
Neurochemical research, 32(10), 1686-1693 (2007-04-04)
Recent studies suggest that iron enters cardiomyocytes via the L-type voltage-gated calcium channel (VGCC). The neuronal VGCC may also provide iron entry. As with calcium, extraneous iron is associated with the pathology and progression of neurodegenerative diseases such as Parkinson's
Eric A Sribnick et al.
Brain research, 1276, 159-170 (2009-04-25)
Estrogen-mediated neuroprotection is observed in neurodegenerative disease and neurotrauma models; however, determining a mechanism for these effects has been difficult. We propose that estrogen may limit cell death in the nervous system tissue by inhibiting increases in intracellular free Ca(2+).
D Rampe et al.
The Journal of pharmacology and experimental therapeutics, 265(3), 1125-1130 (1993-06-01)
We compared the cardiovascular effects of two structurally distinct L-type Ca++ channel activators, the 1,4-dihydropyridine Bay K 8644 and the benzoylpyrrole FPL 64176. Both compounds prolonged action potential duration and enhanced contractility in guinea pig papillary muscle with these responses
Zhong Zhang et al.
American journal of physiology. Renal physiology, 299(4), F862-F871 (2010-07-16)
Multiple voltage-gated Ca(2+) channel (Ca(V)) subtypes have been reported to participate in control of the juxtamedullary glomerular arterioles of the kidney. Using the patch-clamp technique, we examined whole cell Ca(V) currents of pericytes that contract descending vasa recta (DVR). The
Y Zhang et al.
Acta physiologica (Oxford, England), 198(2), 143-158 (2009-11-06)
To investigate the effect of increases in extracellular Ca(2+) entry produced by the L-type Ca(2+) channel agonist FPL-64176 (FPL) upon acute atrial arrhythmogenesis in intact Langendorff-perfused mouse hearts and its dependence upon diastolic Ca(2+) release from sarcoplasmic reticular Ca(2+) stores.
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