E7909
Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
同義詞:
Anti-XPO1
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
共軛:
unconjugated
application:
WB
無性繁殖:
polyclonal
物種活性:
human
citations:
8
技術:
western blot: 2-4 μg/mL using K562 cell lysates
推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~125 kDa
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
western blot: 2-4 μg/mL using K562 cell lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... XPO1(7514)
mouse ... Xpo1(103573)
rat ... Xpo1(85252)
一般說明
Exportin 1/Crm1 (also known as XPO1, Exp1, chromosome region maintenance 1 protein homolog) is mapped to human chromosome 2p15.
應用
Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
生化／生理作用
Exportin 1/Crm1 has been implicated in various steps during mitosis.
Exportin-1 is a protein encoded by the XPO1 gene in humans. It is a novel cell-cycle regulated gene that is essential for the nuclear export signal-dependent nuclear export of proteins. XPO1 is highly expressed in mantle cell lymphoma (MCL) cells. It acts as selective inhibitor of nuclear export (SINE) compounds that induce apoptosis in MCL cells. XPO1 is expressed in subpopulation of Gastric cancer (GC) with aggressive behavior and can serve as a prognosis marker for poor outcome. It has helical hairpin HEAT repeats and a C-terminal helical extension (C-extension). The C-extension helps in regulating CRM1′s cargo-binding affinity by modulating the conformation and flexibility of its HEAT repeats.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
CRM1-mediated nuclear export: to the pore and beyond
Hutten S, et al.
Trends in Cell Biology, 193-201 (2007)
Toshie Sakuma et al.
Journal of virology, 88(8), 4069-4082 (2014-01-31)
Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized. Here, we report the involvement of the
J Schmidt et al.
Leukemia, 27(12), 2357-2365 (2013-06-12)
RNA interference screening identified XPO1 (exportin 1) among the 55 most vulnerable targets in multiple myeloma (MM). XPO1 encodes CRM1, a nuclear export protein. XPO1 expression increases with MM disease progression. Patients with MM have a higher expression of XPO1
Fang Zhou et al.
Medical oncology (Northwood, London, England), 30(4), 726-726 (2013-09-13)
Gastric cancer (GC) is a highly aggressive malignant tumor. Its high mortality rate prompts the urgent need for novel therapeutic agents. The aim of this study is to detect the expression of CRM1 in GC, which has not been reported
Effects of exportin 1 on nuclear transport and meiotic resumption in porcine full-grown and growing oocytes
Onuma A, et al.
Biology of Reproduction, 98(4), 501-509 (2017)
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