推薦產品
產品名稱
Elafin 人, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae
重組細胞
expressed in Saccharomyces cerevisiae
品質等級
化驗
>90% (by MS, HPLC and SDS-PAGE)
形狀
powder
效力
1.7 x 10-10 M Ki (human leukocyte elastase)
4.2 x 10-10 M Ki (human proteinase 3)
分子量
~6 kDa
UniProt登錄號
抗生素活性譜
Gram-negative bacteria
Gram-positive bacteria
作用方式
enzyme | inhibits
運輸包裝
ambient
儲存溫度
−20°C
基因資訊
human ... PI3(5266)
一般說明
Chemical structure: peptide
生化／生理作用
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Viraj J Jasinghe et al.
BioResearch open access, 2(2), 128-137 (2013-04-18)
Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both
Lingling Shu et al.
Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)
Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with
T Dau et al.
Scientific reports, 6, 35413-35413 (2016-10-16)
High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum
J A Caruso et al.
Oncogene, 34(27), 3556-3567 (2014-09-10)
The serine protease inhibitor, elafin, is a critical component of the epithelial barrier against neutrophil elastase (NE). Elafin is downregulated in the majority of breast cancer cell lines compared with normal human mammary epithelial cells (HMECs). Here, we evaluated the
文章
Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.
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