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D9500

Sigma-Aldrich

2′-脱氧鸟苷5′-单磷酸 钠盐 水合物

≥99% (HPLC)

同義詞:

5′-脱氧鸟苷酸, dGMP

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About This Item

經驗公式（希爾表示法）:
C10H14N5O7P · xNa+ · yH2O
分子量：:
347.22 (anhydrous free acid basis)
MDL號碼:
MFCD00150780
分類程式碼代碼:
41106305
PubChem物質ID:
24894297
NACRES:
NA.51

品質等級

200

化驗

≥99% (HPLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

O.[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP(O)([O-])=O)O3)C(=O)N1

InChI

1S/C10H14N5O7P.Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;1H2/q;+1;/p-1/t4-,5+,6+;;/m0../s1

InChI 密鑰

UVKXYXSKMTUDML-FVALZTRZSA-M

相關類別

應用

2′-脱氧鸟苷5′-单磷酸酯（dGMP）用作鸟苷酸激酶（EC 2.7.4.8）的底物，形成dGDP，磷酸化为dGTP后可支持DNA生物合成。dGMP用于研究鸟嘌呤类分子的理化特性。
2′-脱氧鸟苷5′-单磷酸钠盐水合物已被用于：
  • 反相高压力液相色谱（HPLC）分析
  • 确定脱氧单核苷酸对自发增殖的CaCo-2细胞系的影响
  • 确定其刺激免疫细胞生长和功能的能力，并在体外使用流行性感冒病毒抗原作为免疫刺激剂

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

分析證明 (COA)

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Ana-Maria Ruxandra Eftimie et al.
Roumanian archives of microbiology and immunology, 66(1-2), 22-25 (2008-10-22)
Guanylate kinase is a member of the nucleoside monophosphate (NMP) kinase family, a family of enzymes that despite having a low primary structure identity share a similar fold, which consists of three structurally distinct regions termed the CORE, LID, and
Brian G Gentry et al.
Biochemical pharmacology, 81(1), 43-49 (2010-09-18)
Many fraudulent nucleosides including the antivirals acyclovir (ACV) and ganciclovir (GCV) must be metabolized to triphosphates to be active. Cyclopropavir (CPV) is a newer, related guanosine nucleoside analog that is active against human cytomegalovirus (HCMV) in vitro and in vivo.
Mahmoud Kandeel et al.
Molecular and biochemical parasitology, 159(2), 130-133 (2008-04-01)
The present work describes cloning, expression, purification, characterization, and mutation of Plasmodium falciparum guanylate kinase (PlasmoDB ID PFI1420w). Amino-acid sequence alignment revealed important differences especially in K42-V51, Y73-A77, and F100-L110, which include residues important for kinase activity, and at helix
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 22(1), 90-96 (2006)
Global DNA methylation as a possible biomarker for diabetic retinopathy
Maghbooli Z, et al.
Diabetes/metabolism Research and Reviews, 31(2), 183-189 (2015)
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