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Key Documents

D7145

Sigma-Aldrich

2'-脱氧鸟苷 一水合物

99-100%

同義詞:

9-(2-脱氧-β-D-呋喃核糖基)鸟嘌呤, 鸟嘌呤-2′-脱氧核苷

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About This Item

經驗公式(希爾表示法):
C10H13N5O4 · H2O
CAS號碼:
分子量::
285.26
Beilstein:
39814
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

品質等級

化驗

99-100%

形狀

powder

溶解度

1 M NH4OH: 50 mg/mL, clear, colorless

SMILES 字串

O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1

InChI

1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1

InChI 密鑰

LZSCQUCOIRGCEJ-FPKZOZHISA-N

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應用

2′-脱氧鸟苷一水合物作为核苷补充剂,可用于:
  • 研究其对脱氧尿苷激酶(dguok)突变斑马鱼中线粒体DNA拷贝数的影响
  • 在组织培养基中用于合成脱氧核糖核苷酸(dNTP)
  • 在RPMI(Roswell Park Memorial Institute)-1640培养基中用于去除内源性胸腺细胞

生化/生理作用

脱氧鸟苷(dG)是一种嘌呤核苷,在激酶的连续磷酸化作用下可形成脱氧鸟苷三磷酸(dGTP),dGTP可用于通过DNA聚合酶和逆转录酶合成DNA。在四种经典碱基中,脱氧鸟苷是最富电子的碱基,含有多个易受氧化损伤的亲核位点,因此脱氧鸟苷及其氧化衍生物可用于研究核苷和核苷酸的氧化损伤机制。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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José Pedro F Angeli et al.
Free radical biology & medicine, 51(2), 503-515 (2011-05-24)
Epidemiological studies have indicated that Western diets are related to an increase in a series of malignancies. Among the compounds that are credited for this toxic effect are heme and lipid peroxides. We evaluated the effects of hemoglobin (Hb) and
Sreelekha K Singh et al.
Nucleic acids research, 39(15), 6789-6801 (2011-05-17)
The oxidation of DNA resulting from reactive oxygen species generated during aerobic respiration is a major cause of genetic damage that, if not repaired, can lead to mutations and potentially an increase in the incidence of cancer and aging. A
Kasper Broedbaek et al.
Free radical biology & medicine, 51(8), 1473-1479 (2011-08-09)
The increasing prevalence of diabetes together with the associated morbidity and mortality calls for additional preventive and therapeutic strategies. New biomarkers that can be used in therapy control and risk stratification as alternatives to current methods are needed and can
Takeji Takamura-Enya et al.
Bioorganic & medicinal chemistry letters, 21(14), 4206-4209 (2011-06-21)
BODIPY-modified 2'-deoxyguanosine was synthesized for use as a detection reagent for genotoxic compounds. BODIPY-FL is a well known fluorescence reagent whose fluorescent light emission diminishes near a guanine base by a photo-induced electron transfer process. We attached BODIPY-Fl to the
Benjamin Munro et al.
Human molecular genetics, 28(5), 796-803 (2018-11-15)
Deoxyguanosine kinase (dGK) is an essential rate-limiting component of the mitochondrial purine nucleotide salvage pathway, encoded by the nuclear gene encoding deoxyguanosine kinase (DGUOK). Mutations in DGUOK lead to mitochondrial DNA (mtDNA) depletion typically in the liver and brain, causing

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