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重要文件

D5817

Sigma-Aldrich

DMXAA

≥98% (HPLC), solid, apoptosis inducer

同義詞:

5,6-二甲基黄嘌呤-4-乙酸, ASA404, Vadimezan

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About This Item

經驗公式(希爾表示法):
C17H14O4
CAS號碼:
分子量::
282.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

產品名稱

DMXAA, ≥98% (HPLC), solid

品質等級

化驗

≥98% (HPLC)

形狀

solid

顏色

light brown

溶解度

DMSO: soluble >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cc1ccc2C(=O)c3cccc(CC(O)=O)c3Oc2c1C

InChI

1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)

InChI 密鑰

XGOYIMQSIKSOBS-UHFFFAOYSA-N

一般說明

5,6-二甲基呫吨酮-4-乙酸(DMXAA)是一种黄酮乙酸衍生物。可作为血管破坏剂(VDA)起作用,破坏肿瘤血管系统并产生抗肿瘤免疫应答。能引起出血性坏死。

應用

5,6-二甲基呫吨酮-4-乙酸(DMXAA)用于以干扰素基因刺激因子(STING)依赖的方式诱导 I 型 IFN 信号传导。在未感染的情况下,也用于研究 STING 依赖性信号传导。

生化/生理作用

DMXAA是一种细胞凋亡诱导剂;抗血管。

特點和優勢

该化合物是细胞凋亡研究的推荐产品。点击这里 发现更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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存取文件庫

Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
Hou Y, et al.
Immunity, 49(3), 490-503 (2018)
Mark J McKeage
Expert opinion on investigational drugs, 17(1), 23-29 (2007-12-22)
5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is a vascular disrupting agent that has demonstrated efficacy in combination with taxane-based chemotherapy in patients with advanced cancer. Complementary modes of action, a lack of pharmacokinetic interaction and distinct adverse effect profiles provide a strong rationale
Martin Früh et al.
Clinical lung cancer, 14(1), 34-39 (2012-05-29)
Small-cell lung cancer (SCLC) is a highly vascularized tumor. ASA404 is a tumor vascular disrupting agent. This is the first trial to report the effects of combining chemotherapy with ASA404 in SCLC. Patients with untreated metastatic SCLC were treated with
J Guerra et al.
Science advances, 6(21), eaax3333-eaax3333 (2020-06-05)
Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated. Self and non-self-nucleic acids can trigger inflammation, through recognition by the cyclic GMP-AMP (cGAMP) synthetase (cGAS) and subsequent activation of the
Shufeng Zhou et al.
Drug metabolism reviews, 34(4), 751-790 (2002-12-19)
The novel anti-tumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) was developed in the Auckland Cancer Society Research Center. Its pharmacokinetic properties have been investigated using both in vitro and in vivo models, and the resulting data extrapolated to patients. The metabolism of

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