D5193

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

• 同義詞: 17-DMAG
• 經驗公式（希爾表示法）: C₃₂H₄₈N₄O₈
• 分子量：: 616.75
• 分類程式碼代碼: 51102829
• NACRES: NA.85

屬性

• 生物源: synthetic
• 品質等級: 100
• 形狀: powder
• 顏色: dark red-purple to black
• 溶解度: ethanol: ~10 mg/mL (lit.); DMSO: >25 mg/mL (lit.)
• 抗生素活性譜: neoplastics
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C

描述

一般說明

Chemical structure: benzenoid

應用

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).

生化／生理作用

17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

17-DMAG is a more potent analog of geldanamycin. Inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable