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Key Documents

C8417

Sigma-Aldrich

N-(2-氯乙基)-N-乙基-2-溴苄胺 盐酸盐

≥98% (TLC), solid, adrenergic neurotoxin

同義詞:

DSP-4, N-乙基-N-(2-氯乙基)-2-溴苄胺 盐酸盐

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About This Item

經驗公式(希爾表示法):
C11H15BrClN · HCl
CAS號碼:
分子量::
313.06
Beilstein:
4020910
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.77

product name

N-(2-氯乙基)-N-乙基-2-溴苄胺 盐酸盐, ≥98%, solid

品質等級

化驗

≥98%

形狀

solid

顏色

white

溶解度

H2O: 48 mg/mL
0.1 M NaOH: 7 mg/mL
ethanol: soluble

SMILES 字串

Cl[H].CCN(CCCl)Cc1ccccc1Br

InChI

1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H

InChI 密鑰

NDDRNRRNYOULND-UHFFFAOYSA-N

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生化/生理作用

肾上腺素能神经毒素诱导中枢和外周去甲肾上腺素能神经末梢的急性和相对选择性变性。

注意

吸湿的。

準備報告

乙醇、水或0.1N NaOH溶液应在临用前配制。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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P Szot et al.
Neuroscience, 166(1), 279-291 (2010-01-05)
Degeneration of the noradrenergic neurons in the locus coeruleus (LC) is a major component of Alzheimer's (AD) and Parkinson's disease (PD), but the consequence of noradrenergic neuronal loss has different effects on the surviving neurons in the two disorders. Therefore
Harald Engler et al.
Journal of neuroimmunology, 219(1-2), 75-80 (2009-12-25)
The neurotransmitter noradrenaline (NA) plays a pivotal role in immune regulation. Here we used the selective neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to investigate the impact of central NA depletion on cytokine production by splenic monocytes/macrophages and T cells. Intraperitoneal administration of DSP-4
Daniel Jardanhazi-Kurutz et al.
Neurochemistry international, 57(4), 375-382 (2010-02-11)
Degeneration of locus ceruleus neurons and subsequent reduction of norepinephrine concentration in locus ceruleus projection areas represent an early pathological indicator of Alzheimer's disease. In order to model the pathology of the human disease and to study the effects of
T Kushikata et al.
British journal of anaesthesia, 107(6), 924-929 (2011-10-04)
Central noradrenergic neurones have a role in alertness, analgesia, and thermoregulation; these neurones are also involved in the mechanism of anaesthesia. Locus coeruleus neurones innervate various central nervous regions including the cerebral cortex and hippocampus, and are responsible for wakefulness
Anna Sadakierska-Chudy et al.
Biochemical pharmacology, 86(6), 800-807 (2013-08-09)
The aim of the present study was to examine the effect of the brain noradrenergic system on the expression of cytochrome P450 in the liver. The experiment was carried out on male Wistar rats. Intracerebroventricular injection of the noradrenergic neurotoxin

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