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Merck
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重要文件

C4142

Sigma-Aldrich

硫酸卡普霉素 来源于缠绕链霉菌

antibacterial peptide

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About This Item

CAS號碼:
1405-37-4
EC號碼:
215-776-8
MDL號碼:
MFCD00079032
分類程式碼代碼:
51281628
PubChem物質ID:
24892668
NACRES:
NA.85

品質等級

200

形狀

powder

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

DNA synthesis | interferes

儲存溫度

−20°C

SMILES 字串

OS(O)(=O)=O.NCCC[C@H](N)C(=O)NC[C@H]1NC(=O)[C@H](CO)NC(=O)[C@H](N)CNC(=O)[C@@H](NC(=O)\C(NC1=O)=C\NC(N)=O)[C@H]2CCNC(=N)N2

InChI

1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41)(H,38,43)(H3,28,30,37)(H3,29,33,46);(H2,1,2,3,4)/b14-8-;/t10-,11+,12?,13+,15-,16-;/m0./s1

InChI 密鑰

LFFNIXQXRKNZCE-UBBQZPMLSA-N

相關類別

應用

Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.

生化／生理作用

Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It binds across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44 (h44).

準備報告

Sparingly soluble in water.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SLCC9030
SLCC5845
SLBT3170
SLBP9807V
SLBK1425V

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Rashid Akbergenov et al.
Antimicrobial agents and chemotherapy, 55(10), 4712-4717 (2011-07-20)
Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both antibiotics bind across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44
B Reisfeld et al.
Antimicrobial agents and chemotherapy, 56(2), 926-934 (2011-12-07)
The emergence of multidrug-resistant tuberculosis (MDR-TB) has led to a renewed interest in the use of second-line antibiotic agents. Unfortunately, there are currently dearths of information, data, and computational models that can be used to help design rational regimens for
Courtney E Maus et al.
Antimicrobial agents and chemotherapy, 49(2), 571-577 (2005-01-28)
Capreomycin, an important drug for the treatment of multidrug-resistant tuberculosis, is a macrocyclic peptide antibiotic produced by Saccharothrix mutabolis subspecies capreolus. The basis of resistance to this drug was investigated by isolating and characterizing capreomycin-resistant strains of Mycobacterium smegmatis and
Chaiyos Roongruangpitayakul et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(10), 1273-1282 (2013-12-20)
Multi-drug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB) becomes an increasing problem in management. Linezolid has been off-label used in treatment of MDR/XDR-TB with major adverse effects. To study outcomes of MDR/XDR-TB patients treated with linezolid in Central Chest Institute of Thailand. MDR/XDR-TB patients
DeDe Kwun-Wai Man et al.
mSphere, 3(4) (2018-07-20)
The mycobacterial cell wall affords natural resistance to antibiotics. Antimicrobial peptides (AMPs) modify the surface properties of mycobacteria and can act synergistically with antibiotics from differing classes. Here, we investigate the response of Mycobacterium smegmatis to the presence of rifampin
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