K4000

卡那霉素 硫酸酯 来源于卡那霉素链霉菌

Animal Component-free

• 同義詞: 卡那霉素 A, 卡那霉素碱 硫酸盐
• 經驗公式（希爾表示法）: C₁₈H₃₆N₄O₁₁ · H₂O₄S
• CAS號碼: 25389-94-0
• 分子量：: 582.58
• EC號碼: 246-933-9
• MDL號碼: MFCD00070253
• 分類程式碼代碼: 51281654
• PubChem物質ID: 24896236
• NACRES: NA.76

屬性

• 生物源: Streptomyces kanamyceticus
• 品質等級: 200
• 形狀: powder
• 效力: ≥750 μg per mg (dry basis)
• 顏色: white to off-white
• 溶解度: H₂O: 50 mg/mL, clear, colorless to faintly yellow
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; mycoplasma
• 作用方式: protein synthesis | interferes
• SMILES 字串: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
• InChI 密鑰: OOYGSFOGFJDDHP-KMCOLRRFSA-N

描述

一般說明

Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.

應用

Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used:

• in the research of bacterial antibiotic resistance
• in the research on the effect of different antibiotics on bud regeneration

生化／生理作用

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

特點和優勢

High quality antibiotic suitable for mulitple research applications

準備報告

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

儲存和穩定性

Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible

其他說明

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安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360D
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)