K1637

卡那霉素 硫酸酯 来源于卡那霉素链霉菌

meets USP testing specifications, powder

• 同義詞: 卡那霉素 A, 卡那霉素碱 硫酸盐
• 經驗公式（希爾表示法）: C₁₈H₃₆N₄O₁₁ · H₂O₄S
• CAS號碼: 25389-94-0
• 分子量：: 582.58
• EC號碼: 246-933-9
• MDL號碼: MFCD00070253
• 分類程式碼代碼: 51101500
• PubChem物質ID: 24896209
• NACRES: NA.76

屬性

• 生物源: Streptomyces kanamyceticus
• 品質等級: 200
• agency: USP/NF; meets USP testing specifications
• 形狀: powder
• 效力: ≥750 μg per mg
• 儲存條件: (Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible )
• 溶解度: H₂O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; mycoplasma
• 應用: pharmaceutical (small molecule)
• 作用方式: protein synthesis | interferes
• SMILES 字串: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
• InChI 密鑰: OOYGSFOGFJDDHP-KMCOLRRFSA-N

描述

一般說明

Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic purified from the bacterium Streptomyces kanamyceticus. Kanamycin Sulfate is a selection agent for cells in culture media and acts by binding to the 30S subunit of the bacterial ribosome which inhibits protein synthesis in susceptible bacteria.

應用

Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used: in the research of cell type-specific expression of genes

生化／生理作用

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

特點和優勢

• High quality antibiotic suitable for mulitple research applications
• meets USP testing specifications

準備報告

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

其他說明

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安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360D
• 防範說明: P201 - P308 + P313
• 危險分類: Repr. 1B
• 儲存類別代碼: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)