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Merck
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重要文件

C3909

Sigma-Aldrich

D-环丝氨酸

synthetic

同義詞:

(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮

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About This Item

經驗公式(希爾表示法):
C3H6N2O2
CAS號碼:
分子量::
102.09
Beilstein:
80798
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.28

生物源

synthetic

品質等級

形狀

powder

mp

147 °C (dec.) (lit.)

溶解度

water: 50 mg/mL, clear, colorless to light yellow

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

cell wall synthesis | interferes

儲存溫度

−20°C

SMILES 字串

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

InChI 密鑰

DYDCUQKUCUHJBH-UWTATZPHSA-N

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一般說明

Chemical structure: amino acid derivatives

應用

D-cycloserine has been used to inhibit serine hydroxymethyltransferase.

生化/生理作用

作用方式:抑制细胞壁生物合成(D-Ala 肽键形成)。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂;抗革兰氏阴性细菌的抗生素。
干预方式:D-Ala转运干预。

其他說明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Michael Davis et al.
Biological psychiatry, 60(4), 369-375 (2006-08-22)
Administration of benzodiazepines or serotonin reuptake inhibitors in combination with behavior therapy for the treatment of many anxiety disorders has generally lead to only modest gains. In this article we suggest that pharmacotherapy aimed not at treating the symptoms of
Marta Portero-Tresserra et al.
Neurobiology of learning and memory, 100, 1-11 (2012-12-04)
It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or
Ram Maharjan et al.
Molecular biology and evolution, 32(2), 380-391 (2014-11-13)
Evolutionary innovations are dependent on mutations. Mutation rates are increased by adverse conditions in the laboratory, but there is no evidence that stressful environments that do not directly impact on DNA leave a mutational imprint on extant genomes. Mutational spectra
Karyn M Myers et al.
Biological psychiatry, 71(11), 947-955 (2012-05-15)
D-cycloserine (DCS) is an N-methyl-D-aspartate (NMDA) receptor partial agonist that facilitates extinction of conditioned fear in animals and cue exposure therapy (CET) for fear and anxiety disorders in people. Recent preclinical and clinical studies have examined the effect of DCS

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