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69554

Sigma-Aldrich

肽聚糖 来源于枯草芽孢杆菌

同義詞:

PGN

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About This Item

MDL號碼:
分類程式碼代碼:
41116134
NACRES:
NA.21

一般說明

肽聚糖。是一种生物聚合物,是革兰氏阳性菌细胞壁的主要成分。肽聚糖由 N -乙酰基葡糖胺和 N -乙酰基胞壁酸交替单位的碳水化合物骨架组成,并被 D -和 L -氨基酸修饰。 N -乙酰胞壁酸残基与寡肽交联。末端肽为 D -丙氨酸,但其他氨基酸以 D -异构体存在。

應用

肽聚糖可用于裂解酶(如裂解酶)的活性评估。建议使用浓度为 0.15-3μ 的肽聚糖g/ml,溶于水或缓冲液,在 450 nm 处测定。肽聚糖不溶解,但在水中产生混悬液。
肽聚糖可激活 Toll 样受体 2 (TLR2),TLR2 存在于哺乳动物细胞中以刺激淋巴细胞。也可作为 Poly (I:C) 的拮抗剂发挥作用。

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Angela Cuttitta et al.
Fish & shellfish immunology, 67, 86-94 (2017-06-06)
Gene family encoding allograft inflammatory factor-1 (AIF-1) is well conserved among organisms; however, there is limited knowledge in lower organisms. In this study, the first AIF-1 homologue from cnidarians was identified and characterised in the sea anemone Anemonia viridis. The
Yichao Xie et al.
Fish & shellfish immunology, 106, 384-392 (2020-08-11)
Antimicrobial peptide (AMP) is a crucial component of the innate immune system in crustaceans. In mud crab, Scylla paramamosain, a commercially important species, a glycine-rich antimicrobial peptide (Spgly-AMP) gene was newly identified and putatively encoded a 26aa signal peptide and
Christian Stelter et al.
PloS one, 6(6), e20749-e20749 (2011-06-23)
Intestinal inflammation induces alterations of the gut microbiota and promotes overgrowth of the enteric pathogen Salmonella enterica by largely unknown mechanisms. Here, we identified a host factor involved in this process. Specifically, the C-type lectin RegIIIβ is strongly upregulated during
Qian Zhu et al.
Fish & shellfish immunology, 100, 9-17 (2020-03-05)
Interleukin (IL)-11 is a multifunctional cytokine that exerts a series of important immunomodulatory effects and exists in many tissues and cells. A 1106-bp nucleotide sequence representing the complete cDNA of IL-11 was obtained from large yellow croaker (Larimichthys crocea), containing
Yu-Yuan Chen et al.
PloS one, 9(12), e115232-e115232 (2014-12-18)
Invertebrates rely on an innate immune system to combat invading pathogens. The system is initiated in the presence of cell wall components from microbes like lipopolysaccharide (LPS), β-1,3-glucan (βG) and peptidoglycan (PG), altogether known as pathogen-associated molecular patterns (PAMPs), via

文章

Peptidoglycans

The basic structure of peptidoglycan (PGN) contains a carbohydrate backbone of alternating units of N-acetylglucosamine (GlcNAc) and Nacetylmuramic acid, with the N-acetylmuramic acid residues cross-linked to peptides.

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