506350

Pam₃Cys-Ser-（Lys）₄，盐酸盐

≥90% (HPLC), lyophilized solid, TLR1/TLR2 agonist, Calbiochem^®

• 同義詞: Pam₃Cys-Ser-（Lys）₄，盐酸盐, （S）-[2，3-双（棕榈酰氧基）-（2-RS）-丙基]-N-棕榈酰-（R）-Cys-（S）-Ser-（S）-Lys₄-OH，3HCl，P₃CSK₄，3HCl，Pam₃Cys-SK₄，3HCl，Pam3CSK4，TLR1/TLR2激动剂I
• 經驗公式（希爾表示法）: C₈₁H₁₅₆N₁₀O₁₃S · 3HCl
• CAS號碼: 112208-00-1
• 分子量：: 1619.61
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 產品名稱: Pam₃Cys-Ser-（Lys）₄，盐酸盐,
• 化驗: ≥90% (HPLC)
• 品質等級: 100
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated
• 溶解度: water: 2 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72-/m0/s1
• InChI 密鑰: OEDPHAKKZGDBEV-GFPBKZJXSA-N

描述

一般說明

Pam3CSK4 is a selective toll-like receptor 1/2 (TLR1/2) agonist used in the investigation of TLR1/2 function. It is a synthetic lipopeptide for TLR1/2 and mimics the acylated amino terminus of bacterial lipopeptides. Pam3CSK4, with its three lipid chains, facilitates receptor heterodimerization. The two ester-bound lipid chains are inserted into a pocket in TLR2, while the amide-bound lipid chain is inserted into a hydrophobic channel in TLR1. In the context of human uveitis, endophthalmitis, and experimental uveitis models, Pam3CSK4 triggers the expression and secretion of various cytokines and chemokines in intraocular fluids and/or tissues. A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2.

應用

Pam₃Cys-Ser-(Lys)₄, Hydrochloride has been used to stimulate MODE-K cells to access its effects on epithelial neuropilin-1 (NRP1) protein expression. It has been used as a toll-like receptor 2 (TLR2) ligand to study TLR2 functionalities.

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻保存（-20°C）。避免溶液反复冻融。

其他說明

Barrenschee, M., et al. 2010.PLoS One.5, e13889.
Zahringer, U., et al. 2008.Immunology.213, 205.
Toshchakov, V., et al. 2002.Nat. Immunol.3, 392.
Muller, M.R., et al. 2001.Immunology103, 49.
Vergne, I., and Cezanne, L. 1999.Eur. J. Biochem.264, 369.
Diaz-Guerra, M.J., et al. 1996.J. Biol. Chem.271, 30114.
Offermanns, S., et al. 1992.Biochem.J.282, 551.
Seifert, R., et al. 1990.Biochem.J.267, 795.
Hoffmann, P., et al. 1989.Biol. Chem. Hoppe.Seyler.370, 575.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable