B3686

BAY U6751 hydrate

solid, ≥98% (HPLC)

• 同義詞: 4-(2-Chlorophenyl)-1-ethyl-1,4-dihydro-6-methyl-2,3,5-pyridinetricarboxylic acid 5-isopropyl ester disodium salt hydrate
• 經驗公式（希爾表示法）: C₂₀H₂₀ClNNa₂O₆ · xH₂O
• CAS號碼: 114290-51-6
• 分子量：: 451.81 (anhydrous basis)
• MDL號碼: MFCD08705410
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24891730
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: protect from light
• 顏色: white
• 溶解度: H₂O: >8 mg/mL
• 起源: Bayer
• 儲存溫度: 2-8°C
• SMILES 字串: [Na+].[Na+].[H]O[H].CCN1C(C)=C(C(c2ccccc2Cl)C(C([O-])=O)=C1C([O-])=O)C(=O)OC(C)C
• InChI: 1S/C20H22ClNO6.2Na.H2O/c1-5-22-11(4)14(20(27)28-10(2)3)15(12-8-6-7-9-13(12)21)16(18(23)24)17(22)19(25)26;;;/h6-10,15H,5H2,1-4H3,(H,23,24)(H,25,26);;;1H2/q;2*+1;/p-2
• InChI 密鑰: QECLOEJXLYHXNF-UHFFFAOYSA-L

描述

生化／生理作用

BAY U6751 is a glycogen phosphorylase inhibitor. Formed from the prodrug, BAYR3401. BAY U6751 exists as the enantiomeric mixture. BAY W1807 is the active metabolite.

BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output.

特點和優勢

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Light sensitive. Store in amber vials.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves