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Merck
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重要文件

B1901

Sigma-Aldrich

Bradykinin Fragment 2-9

≥97% (HPLC)

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About This Item

經驗公式(希爾表示法):
C44H61N11O10
CAS號碼:
分子量::
904.02
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32

化驗

≥97% (HPLC)

形狀

powder

UniProt登錄號

儲存溫度

−20°C

SMILES 字串

NC(=N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)C(CO)NC(=O)C(Cc3ccccc3)NC(=O)CNC(=O)C4CCCN4C(=O)C5CCCN5)C(O)=O

InChI

1S/C44H61N11O10/c45-44(46)48-20-8-16-30(43(64)65)51-38(59)32(24-28-13-5-2-6-14-28)52-40(61)35-18-10-22-55(35)42(63)33(26-56)53-37(58)31(23-27-11-3-1-4-12-27)50-36(57)25-49-39(60)34-17-9-21-54(34)41(62)29-15-7-19-47-29/h1-6,11-14,29-35,47,56H,7-10,15-26H2,(H,49,60)(H,50,57)(H,51,59)(H,52,61)(H,53,58)(H,64,65)(H4,45,46,48)

InChI 密鑰

ZZHVXIPXTCBVBE-UHFFFAOYSA-N

基因資訊

Amino Acid Sequence

Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

生化/生理作用

Inhibits ACE (angiotensin converting enzyme) and potentiates bradykinin (BK).
The des-arginine-1 bradykinin (BK) peptide (2-9) has no detectable contractile activity, inhibits ACE (angiotensin converting enzyme) and potentiates BK.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Cristiano R Jesse et al.
Pharmacology, biochemistry, and behavior, 91(4), 573-580 (2008-10-22)
The objective of this study was to extend our previous findings by investigating in greater detail the mechanisms that might be involved in the antinociceptive action of p-methoxyl-diphenyl diselenide, (MeOPhSe)(2), in mice. The pretreatment with nitric oxide precursor, l-arginine (600
G S Bedi et al.
Biochimica et biophysica acta, 842(1), 90-99 (1985-09-27)
Four hybridoma cell lines have been established that secrete monoclonal antibodies to nonapeptide bradykinin. Bradykinin coupled to ovalbumin, using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide as coupling agent, was used to immunize BALB/c mice. Spleen cells from the immunized animals were fused to P3-X63-AG8-653 mouse
Julia Laskin et al.
Journal of the American Chemical Society, 125(6), 1625-1632 (2003-02-06)
Time- and collision energy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluorinated self-assembled monolayer (SAM) surface was studied by use of a novel Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments.
B W Busser et al.
The Journal of urology, 160(6 Pt 1), 2267-2273 (1998-11-17)
Bradykinin 1 (B1) receptors have been shown to be upregulated at sites of inflammation. The purpose of this study was to determine the effect of lipopolysaccharide (LPS) on B1 receptor modulation in the isolated mouse bladder. The contractile responses of
S Mohammed et al.
Journal of mass spectrometry : JMS, 36(12), 1260-1268 (2001-12-26)
A novel tandem quadrupole mass spectrometer is described that enables gaseous collision-induced dissociation (CID) and surface-induced dissociation (SID) experiments. The instrument consists of a commercially available triple quadrupole mass spectrometer connected to an SID region and an additional, orthogonal quadrupole

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