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F3261

Sigma-Aldrich

[Glu1]-纤维蛋白肽B 人

≥90% (HPLC)

同義詞:

Fibrinopeptide B

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About This Item

經驗公式（希爾表示法）:
C66H95N19O26
CAS號碼:
103213-49-6
分子量：:
1570.57
MDL號碼:
MFCD00076440
分類程式碼代碼:
12352202
PubChem物質ID:
329799697
NACRES:
NA.32

生物源

human

品質等級

200

化驗

≥90% (HPLC)

形狀

powder

技術

LC/MS: suitable
electrophoresis: suitable

UniProt登錄號

P02675

儲存溫度

−20°C

SMILES 字串

CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)/t32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1

InChI 密鑰

KPBJTGOVJLITON-OECXYHNASA-N

基因資訊

human ... FGB(2244)

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Amino Acid Sequence

Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

一般說明

纤维蛋白肽B （FPB）是在纤维蛋白原被凝血酶裂解为纤维蛋白单体的过程中产生的。它被从纤维蛋白原的氮端& # 946；链切割下来。这种肽由14个氨基酸组成。

應用

[Glu1]-纤维蛋白肽B人类已被用于：
  • LC-MS过程，避免交叉污染并分析质谱仪和LC仪器的性能
  • 用于2D（维）凝胶电泳期间的两点校准和通过质谱鉴定从耻垢分枝杆菌分离的组氨酸（his）-Pup（原核泛素样蛋白）的蛋白质鉴定
  • 用于一维凝胶电泳和串联质谱期间的两点校准，以表征从电气杆菌唾液腺匀浆中获得的可溶性蛋白质样品
  • 作为从胰蛋白酶消化蛋白质二硫键异构酶（PDI）获得的肽上进行的MS和MS / MS获得的数据校正质量漂移的标准

生化／生理作用

纤维蛋白的形成是伤口愈合和炎症的重要因素。纤维蛋白肽B （FPB）也能引起中性粒细胞趋化迁移，而不同时释放溶酶体酶。它是在纤维蛋白原凝固过程中产生的，纤维蛋白原对生理体内平衡至关重要。它涉及各种疾病，如血栓形成和弥散性血管内凝血。

其他說明

从0.1％TFA水溶液中冻干

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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