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Key Documents

B133

Sigma-Aldrich

S)-(−)-Bay K8644

≥98% (HPLC), solid

同義詞:

S-(−)-1,4-二氢-2,6-二甲基-5-硝基-4-[2-(三氟甲基)苯基]-3-吡啶甲酸甲酯

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About This Item

經驗公式(希爾表示法):
C16H15F3N2O4
CAS號碼:
分子量::
356.30
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

顏色

yellow

溶解度

H2O: slightly soluble
ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)

儲存溫度

2-8°C

SMILES 字串

COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O

InChI

1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1

InChI 密鑰

ZFLWDHHVRRZMEI-ZDUSSCGKSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

一般說明

S)-(-)-Bay K8644,一种二氢吡啶化合物,是一种Ca2+ 通道激活剂。它是Bay K 8644的对映异构体。

應用

S)-(-)-Bay K8644已被用作视交叉上核(SCN)切片中的L型钙通道(LTCC)激动剂。它也被用作LTCC激动剂以诱导大鼠心律失常。

生化/生理作用

S)-(-)-Bay K8644增强Ca2+电流,而(+)-Bay K 8644是弱Ca2+通道拮抗剂。Bay K 8644具有亲脂性,可有效清除超氧阴离子。

特點和優勢

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面,请点击此处

法律資訊

经Bayer AG许可生产和销售。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

J J Enyeart et al.
Molecular endocrinology (Baltimore, Md.), 4(5), 727-735 (1990-05-01)
Dihydropyridine (DHP) Ca2+ channel modulators were used to explore the relationship between voltage-gated Ca2+ channels and PRL secretion, synthesis, and mRNA in PRL-secreting pituitary cells. Optical isomers of the Ca2+ channel agonist Bay K 8644 produced stereospecific and opposing effects
Joshua P Whitt et al.
The Journal of general physiology, 150(2), 259-275 (2017-12-15)
Large conductance K+ (BK) channels are expressed widely in neurons, where their activation is regulated by membrane depolarization and intracellular Ca2+ (Ca2+i). To enable this regulation, BK channels functionally couple to both voltage-gated Ca2+ channels (VGCCs) and channels mediating Ca2+
J Ferrante et al.
Biochemical and biophysical research communications, 158(1), 149-154 (1989-01-16)
The 1,4-dihydropyridine Ca2+ channel activator, (-) [3H]Bay K 8644, binds to cardiac membranes and polarized [5 mM K+] and depolarized [50 mM K+] cardiac cells. Binding to microsomal membranes at 25 degrees C indicates a single set of binding sites
Paula Clancy et al.
Journal of atherosclerosis and thrombosis, 23(7), 773-791 (2016-03-08)
Matrix metalloproteinases (MMPs), angiotensin II (AII) and its receptors are implicated in atherosclerotic plaque instability, however the roles of the two receptor subtypes, ATR1 and ATR2, in MMP regulation remain uncertain. In this study, we investigated the effect of ATR1
B K Lawton et al.
British journal of anaesthesia, 108(6), 929-935 (2012-04-19)
Propofol acts as an L-type calcium channel (LTCC) antagonist to decrease peripheral resistance and initiate hypotension. This study investigated LTCC sensitivity/expression in hypertension and the role of LTCCs in exaggerated hypotension to propofol in this situation. Age-matched 12- to 15-week-old

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