196878-M

(±)-Bay K 8644

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

• 同義詞: (±)-Bay K 8644, 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
• 經驗公式（希爾表示法）: C₁₆H₁₅F₃N₂O₄
• 分子量：: 356.30
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 35 mg/mL; ethanol: 35 mg/mL
• 儲存溫度: 2-8°C

描述

一般說明

A synthetic dihydropyridine derivative that is an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

生化／生理作用

Primary Target
L-type Ca2+ channel

警告

Toxicity: Irritant (B)

重構

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.

其他說明

Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.
Weigl, L.G., et al. 2000. J. Physiol.525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun.143, 1107.
Tagliatela, M., et al. 1986. Brain Res.381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol.114, 223.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable