A5353

载脂蛋白B 来源于人类血浆

≥95%, lyophilized powder

• 同義詞: apoB
• MDL號碼: MFCD00130537
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 生物源: human plasma
• 品質等級: 200
• 化驗: ≥95%
• 形狀: lyophilized powder
• UniProt登錄號: P04114
• 運輸包裝: ambient
• 儲存溫度: −20°C
• 基因資訊: human ... APOB(338)

描述

應用

• The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.: This study investigates a variant of ERLIN1 and its role in enhancing TM6SF2 function, highlighting how Apolipoprotein B from human plasma contributes to understanding metabolic-associated liver disease (MASLD) protection (Rendel et al., 2024).


• Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations.: This prospective study evaluates the relationship between blood lipids, lipoproteins, Apolipoprotein B, and the risk of coronary heart disease across diverse populations, providing crucial insights into cardiovascular risk assessment (Deng et al., 2024).


• The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans.: Research in this paper identifies shared pathways in myeloma transformation between mice and humans, utilizing Apolipoprotein B from human plasma to understand the molecular mechanisms involved in this process (Maura et al., 2024).

生化／生理作用

Apo-B水平与冠心病风险相关。Apo-B存在于人体血浆中，有两种异构体，即Apo-B48和Apo-B100。Apo-B100是LDL受体的主要生理配体。Apo-B100是一种大单体蛋白质，包含4563个氨基酸（MW 515 kDa）。Apo-B100在肝脏合成，是VLDL组装所必需的。它不像其他载脂蛋白那样在脂蛋白颗粒之间交换，而在去除载脂蛋白Apo-A、E和C后存在于IDL和LDL中。Apo-B48存在于乳糜微粒及其残留物中。它对于膳食脂质的肠吸收至关重要。
Apo-B48在小肠中合成。它由Apo-B100 N端区域的约一半组成，是转录后mRNA编辑产生终止密码子的结果，这发生于小肠中，而不存在于肝脏中。正常血浆中Apo-B的浓度为~90 mg/dl。

外觀

从含有10 mM脱氧胆酸钠、0.05 M碳酸钠和0.05 M氯化钠的缓冲液（pH 10.0）中冻干

準備報告

用脱氧胆酸钠脱脂。

免責聲明

仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3