A3234

Apolipoprotein E4 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE and HPLC), lyophilized powder

• 同義詞: ApoE4
• MDL號碼: MFCD00285515
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 重組細胞: expressed in E. coli
• 品質等級: 100
• 化驗: ≥90% (SDS-PAGE and HPLC)
• 形狀: lyophilized powder
• UniProt登錄號: P02649
• 儲存溫度: −20°C
• 基因資訊: human ... APOE(348)

描述

一般說明

Apolipoprotein E (ApoE) is present in the brain and is mainly produced by astrocytes. It is a 299 amino acid glycoprotein of 34kDa. It is present in all classes of lipoproteins except LDL (low-density lipoprotein). APOE gene has three alleles, such as APOE ε₃, APOE ε₄ and APOE ε₂. It is located on human chromosome 19q13.

生化／生理作用

ApoE4 (apolipoprotein E4) is associated with AD (Alzheimer′s disease).

Apolipoprotein E4 is a member of the apolipoprotein E family of plasma lipoproteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. ApoE4 regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, regulate the activity of enzymes involved in lipid metabolism and bind amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer′s disease. ApoE exists in three major isoforms: E2, E3, and E4, which differ from one another by a single amino-acid substitution. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

外觀

Lyophillized from a 0.2 μm filtered solution in 20 mM sodium phosphate, pH 7.8.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable