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Key Documents

A1164

Sigma-Aldrich

偶氮丝氨酸

Hybri-Max, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma

同義詞:

O-重氮乙酰基-L-丝氨酸

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About This Item

經驗公式(希爾表示法):
C5H7N3O4
CAS號碼:
分子量::
173.13
Beilstein:
1726602
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:
NACRES:
NA.75

等級

Hybri-Max

品質等級

無菌

γ-irradiated

產品線

BioXtra

形狀

lyophilized powder

技術

cell culture | hybridoma: suitable

雜質

endotoxin, tested

抗生素活性譜

fungi

作用方式

enzyme | inhibits

儲存溫度

−20°C

SMILES 字串

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

InChI 密鑰

MZZGOOYMKKIOOX-VKHMYHEASA-N

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一般說明

Chemical structure: amino acid derivatives

應用

For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.

生化/生理作用

Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.

重構

10mL 无菌细胞培养基可复原一小瓶本品。储备液足以制备 500mL 培养基。最终工作浓度:5.7μM 偶氮丝氨酸。

法律資訊

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Carc. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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存取文件庫

The Pathobiology of Neoplasia, 154-154 (2012)
Antineoplastic and Immunosuppressive Agents, Part 2, 494-494 (2013)
Tusty-Jiuan Hsieh et al.
The Journal of endocrinology, 183(3), 535-550 (2004-12-14)
We reported previously that insulin inhibits the stimulatory effect of high glucose on the expression of angiotensinogen (ANG) gene in both rat immortalized renal proximal tubular cells (IRPTCs) and non-diabetic rat renal proximal tubular cells (RPTCs), but has no effect
Angana Gupta Rajapakse et al.
American journal of physiology. Heart and circulatory physiology, 296(3), H815-H822 (2009-01-13)
Hexosamine biosynthetic pathway (HBP) accounts for some cardiovascular adverse effects of hyperglycemia. We investigated whether the HBP inhibitor azaserine protects against hyperglycemia-induced endothelial damage dependently of HBP. Human endothelial cells isolated from umbilical veins were exposed either to a high
Céline Masclaux-Daubresse et al.
Plant physiology, 140(2), 444-456 (2006-01-13)
Glutamate (Glu) metabolism and amino acid translocation were investigated in the young and old leaves of tobacco (Nicotiana tabacum L. cv Xanthi) using [15N]ammonium and [2-15N]Glu tracers. Regardless of leaf age, [15N]ammonium assimilation occurred via glutamine synthetase (GS; EC 6.1.1.3)

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