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Merck
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文件

50534

Sigma-Aldrich

甘氨鹅脱氧胆酸钠

≥97.0% (TLC)

同義詞:

3α,7α-二羟基-5β-胆烷酸 N-(羧甲基)酰胺 钠盐, N-(3α,7α-二羟基-24-氧代胆烷-24-基)甘氨酸 钠盐, 甘氨鹅脱氧胆酸 钠盐

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About This Item

經驗公式(希爾表示法):
C26H42NNaO5
CAS號碼:
分子量::
471.61
Beilstein:
3847290
MDL號碼:
分類程式碼代碼:
12161902
PubChem物質ID:
NACRES:
NA.77

描述

anionic

化驗

≥97.0% (TLC)

形狀

powder

分子量

471.61 g/mol

技術

protein quantification: suitable

溶解度

H2O: 50 mg/mL, clear, faintly yellow

官能基

amide

SMILES 字串

[Na+].C[C@H](CCC(=O)NCC([O-])=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1

InChI 密鑰

AAYACJGHNRIFCT-YRJJIGPTSA-M

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其他說明

胆固醇增溶能力的研究

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Raúl González et al.
Journal of hepatology, 55(1), 133-144 (2010-12-15)
Reactive oxygen species (ROS) and nitric oxide (NO) exert a relevant role during bile acid-induced hepatotoxicity. Whether α-Tocopherol regulates oxidative and nitrosative stress, bile acid transporter expression and their NO-dependent post-translational modifications, and cell death were assessed in vitro and
M C Carey et al.
Biochemistry, 20(12), 3637-3648 (1981-06-09)
The bile salts chenodeoxycholate (CDC) and its 7 beta-hydroxy epimer ursodeoxycholate (UDC) are administered therapeutically (as acids) to dissolve cholesterol gallstones in man. Since their micellarr solutions and those of their physiological conjugates differ strikingly in their capacities to solubilize
H Higuchi et al.
The Journal of biological chemistry, 276(42), 38610-38618 (2001-08-17)
Toxic bile salts induce hepatocyte apoptosis by both Fas-dependent and -independent mechanisms. In this study, we examined the cellular mechanisms responsible for Fas-independent, bile acid-mediated apoptosis. HuH-7 cells, which are known to be Fas deficient, were stably transfected with the
Kewei Wang et al.
Cellular signalling, 23(10), 1677-1685 (2011-06-23)
Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) can ameliorate apoptosis induced by toxic glycochenodeoxycholate (GCDC) in hepatocytes. However, the underlying molecular mechanisms are not yet understood in detail. This study is to clarify the function of iNOS/NO and
Bodvaël Pennarun et al.
Biochimica et biophysica acta, 1805(2), 123-140 (2009-12-08)
Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are

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