360512

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

• 同義詞: Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
• CAS號碼: 863-57-0
• MDL號碼: MFCD00669624
• 分類程式碼代碼: 12352106
• NACRES: NA.21

屬性

• 品質等級: 100
• 化驗: 100.1% dry basis (titration)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 凝集数: 2.1
• 顏色: white to off-white
• pKa: 3.8
• CMC: 7.1 mM
• 溶解度: water: 200 mg/mL; ethanol: soluble
• 運輸包裝: ambient
• 儲存溫度: 15-25°C
• SMILES 字串: [Na+].N(CC(=O)[O-])C(=O)CCC(C1C2(C(C3C(C4(C(CC3O)CC(CC4)O)C)CC2O)CC1)C)C
• InChI: 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
• InChI 密鑰: OABYVIYXWMZFFJ-UHFFFAOYSA-M

描述

一般說明

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pK_a: 3.8).

應用

Glycocholic Acid, Sodium Salt- is suitable for use:

• as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
• in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
• to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K₁) to analyze its influence on the quality and stability of the mixed micelle systems

生化／生理作用

Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).

警告

Toxicity: Standard Handling (A)

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable