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重要文件

Z2376

Sigma-Aldrich

Zinquin

≥95% (HPLC), solid

同義詞:

2-[[2-Methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]acetic acid, Zinquin A

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About This Item

經驗公式(希爾表示法):
C19H18N2O5S
CAS號碼:
分子量::
386.42
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21

品質等級

化驗

≥95% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: soluble
methanol: soluble

官能基

carboxylic acid

儲存溫度

2-8°C

SMILES 字串

Cc1ccc(cc1)S(=O)(=O)Nc2cc(OCC(O)=O)cc3ccc(C)nc23

InChI

1S/C19H18N2O5S/c1-12-3-7-16(8-4-12)27(24,25)21-17-10-15(26-11-18(22)23)9-14-6-5-13(2)20-19(14)17/h3-10,21H,11H2,1-2H3,(H,22,23)

InChI 密鑰

CGNKOBNGEFZRQU-UHFFFAOYSA-N

應用

Zinquin has been used to detect intracellular zinc.

生化/生理作用

Zinquin is a membrane-permeant fluorophore. It is used to detect zinc in cells by UV fluorescence. Zinquin ethyl ester can be used to monitor the change in intracellular concentrations of Zn2+ in thymocytes and hepatocytes. The ester is excited at 368nm and emits at 490nm.

其他說明

以游离酸或盐的形式提供

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Chris D G and Joseph R L
Reviews in Fluorescence (2007)
Kaya Lutter et al.
Molecular nutrition & food research, 54(2), 285-291 (2009-10-29)
3,3'-Dihydroxyisorenieratene (DHIR) is a structurally unusual carotenoid exhibiting bifunctional antioxidant properties. It is synthesized by Brevibacterium linens, used in dairy industry for the production of red smear cheeses. The compound protects cellular structures against photo-oxidative damage and inhibits the UV-dependent
Géraldine Sarret et al.
Plant physiology, 141(3), 1021-1034 (2006-05-30)
Tobacco (Nicotiana tabacum L. cv Xanthi) plants were exposed to toxic levels of zinc (Zn). Zn exposure resulted in toxicity signs in plants, and these damages were partly reduced by a calcium (Ca) supplement. Confocal imaging of intracellular Zn using
Chiara Devirgiliis et al.
Biochemical and biophysical research communications, 323(1), 58-64 (2004-09-08)
The baker's yeast Saccharomyces cerevisiae was used as a model to visualize intracellular labile zinc under conditions of nutritional zinc imbalance. Zinc-specific staining was performed in yeast cells using both Zinquin fluorescence and zinc-selenium autometallography. Both techniques resulted in specific
Lata Jayaram et al.
Respirology (Carlton, Vic.), 16(3), 459-466 (2011-01-26)
Mouse models of asthma show that zinc deficiency is associated with airway inflammation (AI), which is attenuated by zinc supplements. Whether zinc has a similar role in the human airway remains controversial, with studies demonstrating both high and low plasma

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