SMB01318

3-Hydroxydesloratadine

• 同義詞: 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• 經驗公式（希爾表示法）: C₁₉H₁₉ClN₂O
• CAS號碼: 119410-08-1
• 分子量：: 326.82
• MDL號碼: MFCD00878381
• NACRES: NA.77

屬性

• 描述: Modulation and Signaling
• 品質等級: 100
• 化驗: ≥90%
• 形狀: solid
• 技術: HPLC: suitable
• 顏色: pale yellow to off-white
• 儲存溫度: −20°C
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
• InChI 密鑰: NDFMTPISBHBIKE-UHFFFAOYSA-N

描述

一般說明

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

應用

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

生化／生理作用

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

特點和優勢

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

其他說明

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This product is intended for research purposes only, and it is not meant for human consumption.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable