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重要文件

61739

Sigma-Aldrich

N-月桂酰肌氨酸

purum p.a., ≥98.0% (GC)

同義詞:

N-十二烷酰基-N-甲基甘氨酸, 肌氨酰 L

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About This Item

線性公式:
CH3(CH2)10CON(CH3)CH2COOH
CAS號碼:
分子量::
271.40
Beilstein:
1792084
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21

描述

anionic

品質等級

等級

purum p.a.

化驗

≥98.0% (GC)

分子量

271.40 g/mol

技術

protein quantification: suitable

雜質

≤0.2% water

燃燒殘留物

≤0.1%

mp

45-50 °C

負離子痕跡

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

正離子痕跡

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤70 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤20 mg/kg

官能基

amide
carboxylic acid

SMILES 字串

CCCCCCCCCCCC(=O)N(C)CC(O)=O

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

InChI 密鑰

BACYUWVYYTXETD-UHFFFAOYSA-N

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一般說明

N-月桂酰肌氨酸(N-十二烷酰基-N-甲基甘氨酸,Sarkosyl L,LS)是一种阴离子表面活性剂。已经研究了其在小鼠模型中对单纯疱疹病毒2型(HSV-2)阴道内感染的杀伤作用。

應用

N-月桂酰肌氨酸可用作透皮制剂中的透皮增强剂,因为它能够增强皮肤角质层脂质结构的流动性

象形圖

Skull and crossbonesCorrosion

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Yeu-Chun Kim et al.
International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery
Kunie Ando et al.
The American journal of pathology, 178(2), 803-816 (2011-02-02)
Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mutant tau, we generated a
Yoshiaki Furukawa et al.
The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)
The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here
S Roy et al.
Antimicrobial agents and chemotherapy, 45(6), 1671-1681 (2001-05-17)
The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS
Jian Sun et al.
Nucleic acids research, 43(14), 6827-6846 (2015-07-04)
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation

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