MABN449

Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody

clone 6E12.1, 1 mg/mL, from mouse

• 同義詞: Protein capicua homolog, Protein capicua homolog (CIC)
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 6E12.1, monoclonal
• 物種活性: human, rat
• 濃度: 1 mg/mL
• 技術: immunohistochemistry: suitable (paraffin)
• 同型: IgG1κ
• NCBI登錄號: NP_055940
• UniProt登錄號: Q96RK0
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CIC(23152)

描述

一般說明

Protein capicua homolog (CIC) , also known as Capicua Transcriptional Repressor, Capicua Homolog, and encoded by the gene CIC, is a transcriptional repressor which plays a role in development of the central nervous system (CNS). CIC is a new subfamily of the HMG-box superfamily and the gene′s expression is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS, and thus the gene is implicated in CNS development, in particular in granule cell development. CIC appears to be central to cerebellar development and ErbB signaling as well. Recent research has demonstrated that CIC is highly expressed in certain cancers including medulloblastomas, but also the loss of expression may serve as a biomarker for other cancer types such as oligodendrogliomas.

免疫原

GST-tagged recombinant protein corresponding to human Protein capicua homolog (CIC).

應用

Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Protein capicua homolog (CIC) in human cerebral cortex, rat olfactory bulb, and rat cerebral cortex tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Protein capicua homolog (CIC).

品質

Evaluated by Immunohistochemistry in rat cerebellum tissue.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protein capicua homolog (CIC) in rat cerebellum tissue.

標靶描述

164 kDa calculated

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable