推薦產品
生物源
rabbit
品質等級
100
500
共軛
unconjugated
抗體表格
Ig fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (369A-14)
vial of 0.5 mL concentrate (369A-15)
bottle of 1.0 mL predilute (369A-17)
vial of 1.0 mL concentrate (369A-16)
bottle of 7.0 mL predilute (369A-18)
製造商／商標名
Cell Marque®
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
控制
tonsil
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
nuclear
基因資訊
human ... H3C1(8350)
一般說明
Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis. Therefore, PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in the diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.
品質
 IVD |  IVD |  IVD |  RUO |
聯結
Phosphohistone H3 (PHH3) Positive Control Slides, Product No. 369S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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分析證明 (COA)
Lot/Batch Number
M J Hendzel et al.
The Journal of biological chemistry, 273(38), 24470-24478 (1998-09-12)
Apoptosis plays an important role in the survival of an organism, and substantial work has been done to understand the signaling pathways that regulate this process. Characteristic changes in chromatin organization accompany apoptosis and are routinely used as markers for
Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells.
L R Gurley et al.
European journal of biochemistry, 84(1), 1-15 (1978-03-01)
Michel R Nasr et al.
The American Journal of dermatopathology, 30(2), 117-122 (2008-03-25)
Differentiating malignant melanoma from benign melanocytic lesions can be challenging. We undertook this study to evaluate the use of the immunohistochemical mitosis marker phospho-Histone H3 (pHH3) and the proliferation markers Ki-67 and survivin in separating malignant melanoma from benign nevi.
Howard Colman et al.
The American journal of surgical pathology, 30(5), 657-664 (2006-05-16)
Distinguishing between grade II and grade III diffuse astrocytomas is important both for prognosis and for treatment decision-making. However, current methods for distinguishing between grades based on proliferative potential are suboptimal, making identification of clear cutoffs difficult. In this study
Yoo-Jin Kim et al.
American journal of clinical pathology, 128(1), 118-125 (2007-06-21)
Mitotic activity is one of the most reliable prognostic factors in meningiomas. The identification of mitotic figures (MFs) and the areas of highest mitotic activity in H&E-stained slides is a tedious and subjective task. Therefore, we compared the results from
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