MABF220

Anti-mA20 Antibody/TNFAIP3, clone 37

clone 37, 0.5 mg/mL, from rat

• 同義詞: Tumor necrosis factor alpha-induced protein 3, TNF alpha-induced protein 3, Putative DNA-binding protein A20, Zinc finger protein A20
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rat
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 37, monoclonal
• 物種活性: mouse
• 濃度: 0.5 mg/mL
• 技術: flow cytometry: suitable
• 同型: IgMκ
• NCBI登錄號: NP_033423
• UniProt登錄號: Q60769
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Tnfaip3(21929)

描述

一般說明

TNFAIP3/mA20, also known as Tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, or Zinc finger protein A20, and encoded by the gene TNFAIP3/OTUD7C, is an ubiquitin editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. TNFAIP3/mA20 is involved in immune and inflammatory responses signaled by cytokines or pathogens through the Toll-like receptors and ultimately regulating NF-kappa-B activity. TNFAIP3/mA20 is an essential component of the ubiquitin editing protein complex consisting of RNF11, ICTH, and TAX1BP1 and ensures the transient nature of inflammatory signaling. TNFAIP3/mA20 is also a key player in switching of Lys-63 polyubiquitinated chains to Lys-48 polyubiquitinated chains for the subsequent degradation of specific targets as well. TNFAIP3/mA20 is located in the cytoplasm but can be found in the nucleus and lysosome depending upon the microenvironment and stimulus.

免疫原

Recombinant protein corresponding to Mouse mA20/TNFAIP3.

應用

Detect mA20/TNFAIP3 using this Anti-mA20 Antibody/TNFAIP3, clone 37 validated for use in flow cytometry.

Research Category
Inflammation & Immunology

Research Sub Category
Apoptosis - Additional

標靶描述

90 kDa calculated

外觀

Format: Purified

Purified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable