推薦產品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
1C7, monoclonal
物種活性
human
技術
flow cytometry: suitable
inhibition assay: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... LIFR(3977)
相關類別
一般說明
The LIF receptor is critical in modern mouse stem cell maintenance as the receptor for LIF, the embryonic stem cell (ESC) growth factor that maintains pluripotency and self renewal in mouse ES cells, however physiologically, the importance of LIF-R in real mouse development has been less clear. LIF receptor does play a signaling role and when cleaved its extracellular portion can act as a decoy receptor and block exogenous LIF from performing its function on ES cells. LIF receptor is expressed in multiple tissues in the mouse during development from the liver to the lung and brain. LIF receptor also is important in immune responses and in the stimulation of the interferon response to viral infection. Also LIF receptor has recently been identified as a metastasis suppressor that functions through the Hippo-YAP pathway in humans.
免疫原
Recombinant protein corresponding to mouse LIF Receptor.
應用
Anti-LIF Receptor, clone 1C7 (Azide Free) is an antibody against LIF Receptor for use in FC, Inhibition.
Inhibition Assay Analysis: A representative lot detected LIF Receptor in LIF binding to JAR cells (Blanchard, F., et al. (1997) International Immunology. 9(12):1775-1784).
Inhibition Assay Analysis: A representative lot detected LIF Receptor in IL3 proliferative response in Ba/F3 cells (Pitard, V., et al. (1997) Journal of Immunological Methods. 205:177-190).
Inhibition Assay Analysis: A representative lot detected LIF Receptor in IL3 proliferative response in Ba/F3 cells (Pitard, V., et al. (1997) Journal of Immunological Methods. 205:177-190).
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
品質
Evaluated by Flow Cytometry in CHO D1IgD2-mycDAF cells .
Flow Cytometry Analysis: 1.0 µg of this antibody detected LIF Receptor in CHO D1IgD2-mycDAF.
Flow Cytometry Analysis: 1.0 µg of this antibody detected LIF Receptor in CHO D1IgD2-mycDAF.
標靶描述
123 kDa calculated
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.
Voisin, MB; Bitard, J; Daburon, S; Moreau, JF; Taupin, JL
The Journal of Biological Chemistry null
Epitope-function relationships of human leukemia inhibitory factor receptors using a novel set of anti-gp190 mAB.
Blanchard, F; Pitard, V; Taupin, JL; Raher, S; Hallet, MM; Moreau, JF; Godard, A; Jacques, Y
International Immunology null
V Pitard et al.
Journal of immunological methods, 205(2), 177-190 (1997-07-14)
Leukemia inhibitory factor (LIF), oncostatin-M (OSM), ciliary neurotrophic factor (CNTF) and cardiotrophin-1 (CT1) act through transmembrane receptors which share the gp190 glycoprotein chain. The understanding of its involvement in the biology of these cytokines is of importance since these systems
J L Taupin et al.
The Journal of biological chemistry, 276(51), 47975-47981 (2001-10-19)
The receptor for the cytokine leukemia inhibitory factor (LIF) associates the low affinity binding component gp190 and the high affinity converter gp130, both of which are members of the family of hematopoietic receptors characterized by the cytokine receptor homology (CRH)
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