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Merck
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重要文件

MAB2624

Sigma-Aldrich

抗内皮粘蛋白抗体,克隆V.5C7

clone V.5C7, from rat

同義詞:

Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14, Endomucin-1/2

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rat

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

V.5C7, monoclonal

物種活性

mouse

技術

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG1κ

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

mouse ... Emcn(59308)

一般說明

内啡肽是一种内皮唾液分泌蛋白,属于一类糖蛋白,特征是高水平的o -糖解离和丰富的唾液酸。它可以抑制黏附聚集并阻碍细胞外基质和细胞的相互作用。在肾、心、脑、肝、肺、脾和胸腺中表达最多。内啡肽只存在于内皮细胞中。

免疫原

小鼠内皮粘蛋白细胞

應用

免疫沉淀分析: 一个先前批次已被独立实验室用于bEND细胞裂解物的IP(Morgan, 1999)。

免疫组织化学分析: 一个先前批次已被独立实验室用于小鼠舌头、心脏、子宫、大脑和小肠冷冻和石蜡包埋组织切片的免疫组织化学染色(Morgan, 1999)。

流式细胞术分析: 一个先前批次已被独立实验室用于转染COS-7细胞的FC(Morgan, 1999)。
抗内皮粘蛋白抗体,克隆V.5C7可检测内皮粘蛋白水平,已发布,经验证可用于WB、IP、IH、FC。
研究子类别
细胞器&细胞标志物

粘附(CAM)

品質

已通过蛋白质印迹在小鼠内皮瘤细胞系中进行了评估。

蛋白质印迹分析: 0.0025 µg/mL该抗体可在10 µg的bEND3细胞裂解液中检测到内皮粘蛋白。

標靶描述

观察值为~ 75kDa

外觀

形式:纯化

分析報告

对照
bEND3细胞裂解液

其他說明

浓度:请参考批次特异性浓缩物的检验报告。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Nelida Olave et al.
American journal of physiology. Lung cellular and molecular physiology, 315(4), L535-L544 (2018-06-29)
Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment of lung development in newborn animals and is increased in the lungs of human infants with bronchopulmonary dysplasia (BPD). COX-2 catalyzes the production of cytoprotective prostaglandins, such as prostacyclin (PGI2), as well as proinflammatory mediators
Meghan Grojean et al.
Journal of cellular and molecular medicine, 25(11), 4950-4961 (2021-05-04)
Elevated expression of multiple growth factors and receptors including c-Met and VEGFR has been reported in gastric adenocarcinoma (GAC) and thus provides a potentially useful therapeutic target. The therapeutic efficacy of foretinib, a c-Met/VEGFR2 inhibitor, was determined in combination with
Kate Crawford et al.
Cancer biology & therapy, 22(10-12), 619-629 (2021-12-10)
Standard chemotherapy regimens for gastric adenocarcinoma (GAC) have limited efficacy and considerable toxicity profiles. Nab-paclitaxel has shown promising antitumor benefits in previous GAC preclinical studies. Dovitinib inhibits members of the receptor tyrosine kinase family including FGFR, VEGFR and PDGFR, and
Sathiyanarayanan Manivannan et al.
Communications biology, 5(1), 820-820 (2022-08-16)
Congenital heart disease (CHD) is the most prevalent birth defect, often linked to genetic variations, environmental exposures, or combination of both. Epidemiological studies reveal that maternal pregestational diabetes is associated with ~5-fold higher risk of CHD in the offspring; however
Niranjan Awasthi et al.
Cancer letters, 358(1), 59-66 (2014-12-21)
Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3

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