ABS446

Anti-GPVI Antibody

from rabbit, purified by affinity chromatography

• 同義詞: GPVI Antibody, Glycoprotein VI, GPIV, Platelet glycoprotein VI precursor, GP6, Glycoprotein 6
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, human
• 技術: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt登錄號: Q9HCN6
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GP6(51206)

描述

一般說明

Glycoprotein 6 (GP6), or glycoprotein VI (GPVI), is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. GP6 is a collagen receptor involved in collagen-induced platelet adhesion and activation, and may contribute to arterial and venous thrombus formation. GP6 is a membrane glycoprotein that plays a crucial role in platelet procoagulant activity and subsequent thrombin and fibrin formation. GP6 is expressed in megakaryocytes and platelets. The signaling pathway of GP6 involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. It has been shown that bleeding disorders such as Bleeding Disorder Platelet-Type 11 (BDPLT11), a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen, is caused by defects in GP6.

特異性

This antibody recognizes the C-terminus of GPVI.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human GPVI.

應用

Anti-GPVI Antibody is a highly specific rabbit polyclonal antibody, that targets Glycoprotein 6 & has been tested in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected GPVI in human heart tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPVI in human heart cells.

品質

Evaluated by Western Blotting/Peptide Inhibition Assay in A20 cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected GPVI in 15 µg of A20 cell lysate.

標靶描述

~115 kDa observed. Uniprot describes 3 isoforms at ~35 kDa, ~37 kDa, and ~67 kDa

聯結

Replaces: MABT473

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable