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Merck
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Key Documents

ABN1739M

Sigma-Aldrich

Anti-Utrophin A

from rabbit

同義詞:

UTRN A

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

human, mouse

包裝

antibody small pack of 25 μg

技術

immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

同型

IgG

NCBI登錄號

UniProt登錄號

目標翻譯後修改

unmodified

基因資訊

human ... UTRN(7402)

一般說明

Utrophin A (UniProt: E9Q6R7) is encoded by the Utrn gene in murine species. Utrophin is a large cytoskeletal protein, which is autosomally-encoded homologue of dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene. It displays a sequence homology with dystrophin and possesses many of the protein-binding properties ascribed to dystrophin. In normal skeletal muscle, utrophin is located at the neuromuscular junction and dystrophin predominates at the sarcolemma. During development and in certain myopathies utrophin is also reported to be present at the sarcolemma and this redistribution is associated with higher levels of utrophin. Utrophin is found to co-localize with the acetylcholine receptors at the neuromuscular junctions and may participate in stabilizing the synaptic cytoskeleton. The utrophin mRNA contains two full-length species (named A- and B-utrophin), which are transcribed from different promoters. Hence, utrophin is a composite of A- and B-utrophin and only the A-utrophin is up-regulated in dystrophin-deficient striated muscle. This up-regulation is reported to occur post-transcriptionally. Utrophin A and B differ in their N-termini sequence. (Ref.: Blake, DJ et al. (1996). Brain Pathol. 6(1); 37-47; Weir, AP et al. (2002). J. Biol. Chem. 277 (47); 45285-90).

特異性

This rabbit polyclonal antibody detects utrophin in human and mouse muscle tissue. It targets an epitope with in the first 26 amino acids from the N-terminal region.

免疫原

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the first 26 amino acids from the N-terminal region of murine utrophin.

應用

Anti-Utrophin A Antibody, Cat. No. ABN1739, is a highly specific rabbit polyclonal antibody that targets Utrophin and has been tested in Immunofluorescence, Immunohistochemistry (Paraffin), and Western Blotting.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Utrophin A in human skeletal muscle and human uterus tissue.

Immunofluorescence Analysis: A representative lot detected Utrophin A in quadriceps transverse sections in transgenic mice (Adams, M.E., et. al. (2010). J Neurosci. 30(33):11004-10).

Immunohistochemistry Analysis: A representative lot detected Utrophin A in frozen sections of the gastrocnemius muscles (Banks, G.B., et. al. (2014). PLoS Genet. 10(6):e1004431).

Western Blotting Analysis: representative lot detected Utrophin A in whole muscle lysates (Banks, G.B., et. al. (2014). PLoS Genet. 10(6):e1004431).

Western Blotting Analysis: A representative lot detected Utrophin A in muscle membrane extracts from mdx mice (Courtesy of Dr Marvin Adams at University of Washington).

Immunofluorescence Analysis: A representative lot detected Utrophin A in mouse neuromuscular junction (Courtesy of Dr Marvin Adams at University of Washington).
Research Category
Neuroscience

品質

Evaluated by Immunohistochemistry in human prostate.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Utrophin A in human prostate tissue.

標靶描述

394.47 kDa calculated.

外觀

Affinity Purified
Format: Purified
Purified rabbit polyclonal antibody in PBS with 0.02% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

does not flash

閃點(°C)

does not flash


分析證明 (COA)

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